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Protein Page:
TfR (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
TfR the transferrin receptor. Regulates the cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied receptors into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, misc.; Cell surface
Chromosomal Location of Human Ortholog: 3q29
Cellular Component: basolateral plasma membrane; cell surface; coated pit; cytoplasmic membrane-bound vesicle; endosome; external side of plasma membrane; extracellular region; extracellular space; integral to plasma membrane; intracellular membrane-bound organelle; perinuclear region of cytoplasm; plasma membrane; recycling endosome
Molecular Function: double-stranded RNA binding; glycoprotein binding; identical protein binding; protein binding; protein homodimerization activity; transferrin receptor activity
Biological Process: regulation of cell growth; regulation of cell proliferation; transferrin transport
Disease: Immunodeficiency 46
Reference #:  P02786 (UniProtKB)
Alt. Names/Synonyms: CD71; p90; sTfR; T9; TfR; TfR1; TFRC; transferrin receptor (p90, CD71); Transferrin receptor protein 1; Transferrin receptor protein 1, serum form; Trfr
Gene Symbols: TFRC
Molecular weight: 84,871 Da
Basal Isoelectric point: 6.18  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TfR

Protein Structure Not Found.
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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S7‑p _MMDQARsAFsNLFG
0 2 S10‑p DQARsAFsNLFGGEP
0 30 S19‑p LFGGEPLsytRFsLA
1 1067 Y20‑p FGGEPLsytRFsLAR
0 42 T21‑p GGEPLsytRFsLARQ
3 20 S24‑p PLsytRFsLARQVDG
0 8 S34‑p RQVDGDNsHVEMkLA
0 27 K39‑ub DNsHVEMkLAVDEEE
0 2 T52‑p EENADNNtkANVTkP
0 1 K53‑ac ENADNNtkANVTkPk
0 39 K53‑ub ENADNNtkANVTkPk
0 2 K58‑ub NtkANVTkPkRCSGS
0 4 K60‑ub kANVTkPkRCSGSIC
0 1 T104‑ga ECERLAGtEsPVREE
0 2 S106‑p ERLAGtEsPVREEPG
0 1 Y123‑p FPAARRLyWDDLkRK
0 1 K128‑ac RLyWDDLkRKLSEKL
0 1 K128‑sc RLyWDDLkRKLSEKL
0 1 K145‑ub TDFTGTIkLLNENSY
0 1 K161‑ub PREAGSQkDENLALy
0 1 K161‑sc PREAGSQkDENLALy
0 1 Y168‑p kDENLALyVENQFRE
0 1 S195‑p VKIQVKDsAQNsVII
0 1 S199‑p VKDsAQNsVIIVDkN
0 1 K205‑ub NsVIIVDkNGRLVYL
0 1 Y219‑p LVENPGGyVAYSkAA
0 1 K224‑ub GGyVAYSkAATVTGK
0 7 Y282‑p NAIGVLIyMDQtKFP
0 7 T286‑p VLIyMDQtKFPIVNA
0 1 S326‑p TQFPPSRssGLPNIP
0 1 S327‑p QFPPSRssGLPNIPV
0 1 S338‑p NIPVQTIsRAAAEKL
0 1 D352 LFGNMEGDCPSDWKT
0 1 S368 STCRMVTSESKNVKL
0 1 K382‑ub LTVSNVLkEIKILNI
0 1 K382‑sc LTVSNVLkEIKILNI
0 1 K394‑ac LNIFGVIkGFVEPDH
0 1 Y402‑p GFVEPDHyVVVGAQR
0 1 K418‑ac AWGPGAAksGVGTAL
0 2 K418‑ub AWGPGAAksGVGTAL
0 1 S419‑p WGPGAAksGVGTALL
0 1 Y481‑p LHLKAFTyINLDKAV
0 1 S497 GTSNFKVSAsPLLyT
0 2 S499‑p SNFKVSAsPLLyTLI
0 1 Y503‑p VSAsPLLyTLIEKTM
0 1 Y523‑p PVTGQFLyQDSNWAS
0 1 K531‑ub QDSNWASkVEKLTLD
0 1 T572‑p YLGTTMDtyKELIER
0 1 Y573‑p LGTTMDtyKELIERI
0 1 Y611‑p DVELNLDyERYNsQL
0 1 S616‑p LDyERYNsQLLsFVR
0 1 S620‑p RYNsQLLsFVRDLNQ
0 1 T658‑p RATSRLTtDFGNAEk
0 1 K665‑ub tDFGNAEkTDRFVMK
0 1 Y683‑p DRVMRVEyHFLsPYV
0 1 S687‑p RVEyHFLsPYVsPkE
0 1 S691‑p HFLsPYVsPkESPFR
0 2 K693‑ub LsPYVsPkESPFRHV
0 1 K693‑sc LsPYVsPkESPFRHV
  mouse

 
S7 _MMDQARSAFSNLFG
S10 DQARSAFSNLFGGEP
S19‑p LFGGEPLsytRFsLA
Y20‑p FGGEPLsytRFsLAR
T21‑p GGEPLsytRFsLARQ
S24‑p PLsytRFsLARQVDG
S34‑p RQVDGDNsHVEMkLA
K39‑ub DNsHVEMkLAADEEE
M52 EENADNNMkASVRKP
K53 ENADNNMKASVRKPK
K53‑ub ENADNNMkASVRKPK
K58 NMkASVRKPKRFNGR
K60 kASVRKPKRFNGRLC
T104 ECVKLAETEETDKSE
E106 VKLAETEETDKSETM
Y125 VPTSSRLYWADLKTL
K130 RLYWADLKTLLSEKL
K130 RLYWADLKTLLSEKL
K147 IEFADTIKQLSQNTY
K163 PREAGSQKDESLAYY
K163 PREAGSQKDESLAYY
Y170 KDESLAYYIENQFHE
S197 VKIQVKSSIGQNMVT
N201 VKSSIGQNMVTIVQS
Q207 QNMVTIVQSNGNLDP
Y221 PVESPEGYVAFSKPT
K226 EGYVAFSKPTEVSGK
Y284 NAIGVLIYMDKNKFP
N288 VLIYMDKNKFPVVEA
S328 TQFPPSQSSGLPNIP
S329 QFPPSQSSGLPNIPV
S340 NIPVQTISRAAAEKL
S354‑p LFGKMEGsCPARWNI
S370‑p SSCKLELsQNQNVKL
K384 LIVKNVLKERRILNI
K384 LIVKNVLKERRILNI
K396 LNIFGVIKGYEEPDR
Y404 GYEEPDRYVVVGAQR
K421 LGAGVAAKSSVGTGL
K421 LGAGVAAKSSVGTGL
S422 GAGVAAKSSVGTGLL
Y484 LHLKAFTYINLDKVV
S500‑p GTSNFKVsASPLLYT
S502 SNFKVsASPLLYTLM
Y506 VsASPLLYTLMGKIM
Y526 PVDGKSLYRDSNWIS
K534 RDSNWISKVEKLSFD
T575 YLGTRLDTYEALTQK
Y576 LGTRLDTYEALTQKV
Y614 DVELNLDYEMYNSKL
S619 LDYEMYNSKLLSFMK
S623 MYNSKLLSFMKDLNQ
T661 RATSRLTTDFHNAEK
K668 TDFHNAEKTNRFVMR
Y686 DRIMKVEYHFLSPYV
S690 KVEYHFLSPYVSPRE
S694 HFLSPYVSPRESPFR
R696 LSPYVSPRESPFRHI
R696 LSPYVSPRESPFRHI
  rat

 
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
K8 IEFTDIIKQLSQNTY
K24 PREAGSQKDENLAYY
K24 PREAGSQKDENLAYY
Y31 KDENLAYYIENLFHD
S58 VKIQVKNSVSQNLVT
N62 VKNSVSQNLVTINSG
N67 SQNLVTINSGSNIDP
Y81 PVEAPEGYVAFSKAG
K86 EGYVAFSKAGEVTGK
Y144 NAIGVLIYMDRNTFP
N148 VLIYMDRNTFPVVEA
S188 TQFPPSQSSGLPSIP
S189 QFPPSQSSGLPSIPV
S200 SIPVQTISRAPAEKL
N214 LFKNMEGNCPPSWNI
S230 SSCKLELSQNQNVKL
K244 LTVNNVLKETRILNI
K244 LTVNNVLKETRILNI
K256 LNIFGVIKGYEEPDR
Y264 GYEEPDRYIVVGAQR
K280 AWGPGVAKSSVGTGL
K280 AWGPGVAKSSVGTGL
S281 WGPGVAKSSVGTGLL
Y343 LHLKAFTYINLDKVV
S359 GTSNFKVSASPLLYT
S361 SNFKVSASPLLYTLM
Y365 VSASPLLYTLMGKIM
Y385 PIDGKYLYRNSNWIS
K393 RNSNWISKIEELSLD
T434 YLGTKLDTYEILIQK
Y435 LGTKLDTYEILIQKV
Y473 DIELTLDYEMYNSKL
S478 LDYEMYNSKLLSFMK
S482 MYNSKLLSFMKDLNQ
T520 RATSRLTTDFHNAEK
K527 TDFHNAEKTNRFVMR
Y545 DRIMKVEYHFLSPYV
S549 KVEYHFLSPYVSPRE
S553 HFLSPYVSPRESPFR
R555 LSPYVSPRESPFRHI
R555 LSPYVSPRESPFRHI
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