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Protein Page:
TNFRSF11A (human)

Overview
TNFRSF11A Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL-mediated osteoclastogenesis. Involved in the regulation of interactions between T-cells and dendritic cells. Binds to the clefts between the subunits of the TNFSF11 ligand trimer to form a heterohexamer. Interacts with TRAF1, TRAF2, TRAF3, TRAF5 and TRAF6. Interacts (via cytoplasmic domain) with GAB2. Ubiquitous expression with high levels in skeletal muscle, thymus, liver, colon, small intestine and adrenal gland. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 18q22.1
Cellular Component: external side of plasma membrane; integral to plasma membrane; plasma membrane
Molecular Function: cytokine binding; metal ion binding; protein binding; receptor activity; transmembrane receptor activity; tumor necrosis factor receptor activity
Biological Process: activation of NF-kappaB transcription factor; adaptive immune response; cell-cell signaling; circadian thermoregulation; inflammatory response; lymph node development; monocyte chemotaxis; ossification; osteoclast differentiation; positive regulation of cell proliferation; positive regulation of JNK activity; positive regulation of transcription factor activity; regulation of apoptosis; response to cytokine stimulus; response to lipopolysaccharide; response to radiation; signal transduction; tumor necrosis factor-mediated signaling pathway
Disease: Familial Expansile Osteolysis; Osteopetrosis, Autosomal Recessive 7; Paget Disease Of Bone
Reference #:  Q9Y6Q6 (UniProtKB)
Alt. Names/Synonyms: CD265; FEO; LOH18CR1; loss of heterozygosity, 18, chromosomal region 1; ODFR; OFE; OPTB7; Osteoclast differentiation factor receptor; OSTS; PDB2; RANK; Receptor activator of NF-KB; receptor activator of nuclear factor-kappa B; TNFRSF11A; TNR11; TRANCER; Tumor necrosis factor receptor superfamily member 11A; tumor necrosis factor receptor superfamily, member 11a, activator of NFKB; tumor necrosis factor receptor superfamily, member 11a, NFKB activator
Gene Symbols: TNFRSF11A
Molecular weight: 66,034 Da
Basal Isoelectric point: 5.21  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TNFRSF11A

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S197 SDAVCSSSLPARKPP
0 1 S463‑p DCEPLVGsPKRGPLP
0 14 S580‑p ETLARRDsFAGNGPR
  mouse

 
S198‑p SDVVCSSsMTLRRPP
S457 DHEPFPGSLKCGPLP
S571 ETLAHRDSFAGTAPR
  rat

 
S198 SDVVCSSSLTLIKPP
S457 DHEPLPGSLKCGPLP
S579 ETLAHRDSFAGTAPR
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