regulates mitochondrial transcription. Induced in humans by caloric restriction. Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase. Activates transcription by binding immediately upstream of transcriptional start sites. Is able to unwind and bend DNA. Involved in cisplatin resistance. Interacts with TFB1M and TFB2M. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription regulation
Molecular Function: chromatin binding; DNA bending activity; protein binding; RNA binding; transcription factor activity
Biological Process: DNA-dependent DNA replication; mitochondrion organization and biogenesis; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of transcription from RNA polymerase I promoter; transcription from mitochondrial promoter; transcription initiation from mitochondrial promoter