Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
HomeAbout PhosphoSiteUsing PhosphoSiteprivacy & cookiesCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Protein Page:
SYVN1 (human)

SYVN1 Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation. Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Also promotes the degradation of normal but naturally short-lived proteins such as SGK. Protects cells from ER stress-induced apoptosis. Protects neurons from apoptosis induced by polyglutamine-expanded huntingtin (HTT) or unfolded GPR37 by promoting their degradation. Sequesters p53/TP53 in the cytoplasm and promotes its degradation, thereby negatively regulating its biological function in transcription, cell cycle regulation and apoptosis. Belongs to the HRD1 family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC 6.3.2.-; EC; Endoplasmic reticulum; Ligase; Membrane protein, integral; Membrane protein, multi-pass; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of Human Ortholog: 11q13
Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane; membrane; nucleoplasm; smooth endoplasmic reticulum
Molecular Function: ATPase binding; chaperone binding; protein binding; unfolded protein binding
Biological Process: ER-associated protein catabolic process; protein amino acid N-linked glycosylation via asparagine; protein stabilization; protein ubiquitination; protein ubiquitination during ubiquitin-dependent protein catabolic process; retrograde protein transport, ER to cytosol; unfolded protein response
Reference #:  Q86TM6 (UniProtKB)
Alt. Names/Synonyms: E3 ubiquitin-protein ligase synoviolin; HRD1; KIAA1810; MGC40372; Synovial apoptosis inhibitor 1; synovial apoptosis inhibitor 1, synoviolin; SYVN1
Gene Symbols: SYVN1
Molecular weight: 67,685 Da
Basal Isoelectric point: 6.47  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  ENZYME  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene