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Protein Page:
SIRT6 (human)

Overview
SIRT6 NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF- kappa-B target genes. Acts as a corepressor of the transcription factor HIF1A to control the expression of multiple glycolytic genes to regulate glucose homeostasis. Required for genomic stability. Regulates the production of TNF protein. Has a role in the regulation of life span. Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. On DNA damage, promotes DNA end resection via deacetylation of RBBP8. Has very weak deacetylase activity and can bind NAD(+) in the absence of acetylated substrate. Interacts with RELA. Interacts with RBBP8; the interaction deacetylates RBBP8. Belongs to the sirtuin family. Class IV subfamily. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Deacetylase; EC 2.4.2.31; EC 3.5.1.-; Transferase
Chromosomal Location of Human Ortholog: 19p13.3
Cellular Component: nuclear telomeric heterochromatin; nucleolus; nucleoplasm; nucleus
Molecular Function: NAD(P)+-protein-arginine ADP-ribosyltransferase activity; NAD+ ADP-ribosyltransferase activity; NAD-dependent histone deacetylase activity; NAD-dependent histone deacetylase activity (H3-K9 specific); protein binding; zinc ion binding
Biological Process: positive regulation of chromatin silencing at telomere; positive regulation of telomere maintenance; protein amino acid ADP-ribosylation
Reference #:  Q8N6T7 (UniProtKB)
Alt. Names/Synonyms: NAD-dependent deacetylase sirtuin-6; SIR2-like protein 6; sir2-related protein type 6; SIR2L6; SIRT6; sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae); sirtuin type 6
Gene Symbols: SIRT6
Molecular weight: 39,119 Da
Basal Isoelectric point: 9.31  Predict pI for various phosphorylation states
CST Pathways:  Protein Acetylation
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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SIRT6

Protein Structure Not Found.
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