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Protein Page:
FLNB (human)

Overview
FLNB a ubiquitous cytoskeletal protein that links actin filaments to membrane glycoproteins. Six alternatively spliced isoforms have been described. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoforms 1 and 2 are expressed in placenta, bone marrow, brain, umbilical vein endothelial cells, retina and skeletal muscle. Isoform 1 is predominantly expressed in prostate, uterus, liver, thyroid, stomach, lymph node, small intestine, spleen, skeletal muscle, kidney, placenta, pancreas, heart, lung, platelets, endothelial cells, megakaryocytic and erythroleukemic cell lines. Isoform 2 is predominantly expressed in spinal cord and platelets. Also expressed in thyroid adenoma, neurofibrillary tangles (NFT), senile plaques in the hippocampus and cerebral cortex in Alzheimer's disease. Isoform 3 and isoform 6 are expressed predominantly in lung, heart, skeletal muscle, testis, spleen, thymus and leukocytes. Isoform 4 and isoform 5 are expressed in heart. Note: This description may include information from UniProtKB.
Protein type: Actin-binding; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 3p14.3
Cellular Component: actin cytoskeleton; cell-cell adherens junction; cytoplasm; cytosol; extracellular matrix; focal adhesion; plasma membrane
Molecular Function: identical protein binding; protein binding
Biological Process: cytoskeletal anchoring; signal transduction
Disease: Atelosteogenesis, Type I; Atelosteogenesis, Type Iii; Boomerang Dysplasia; Larsen Syndrome; Spondylocarpotarsal Synostosis Syndrome
Reference #:  O75369 (UniProtKB)
Alt. Names/Synonyms: ABP-278; ABP-280; ABP-280 homolog; actin binding protein 278; Actin-binding-like protein; AOI; Beta-filamin; DKFZp686A1668; DKFZp686O033; Fh1; filamin 1 (actin-binding protein-280)-like; filamin B, beta; Filamin homolog 1; Filamin-3; Filamin-B; FLN-B; FLN1L; FLN3; FLNB; LRS1; SCT; TABP; TAP; Thyroid autoantigen; Truncated ABP; Truncated actin-binding protein
Gene Symbols: FLNB
Molecular weight: 278,164 Da
Basal Isoelectric point: 5.47  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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FLNB

Protein Structure Not Found.
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