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Protein Page:
CD3E (human)
rdtyret
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CD3E a T cell surface glycoprotein that is a component of the T cell antigen receptor. The recruitment of Nck by CD3 epsilon reveals a ligand-induced conformational change essential for T cell receptor signaling and synapse formation. Contains 1 immunoglobulin-like domain and 1 ITAM domain. Note: This description may include information from UniProtKB.
Protein type: Receptor, misc.; Membrane protein, integral
Chromosomal Location of Human Ortholog: 11q23
Cellular Component: alpha-beta T cell receptor complex; external side of plasma membrane; immunological synapse; integral to plasma membrane; intercellular junction; intracellular; plasma membrane; T cell receptor complex
Molecular Function: protein binding; protein heterodimerization activity; protein kinase binding; receptor signaling complex scaffold activity; receptor signaling protein activity; SH3 domain binding; T cell receptor binding; transmembrane receptor activity
Biological Process: cell surface receptor linked signal transduction; G-protein coupled receptor protein signaling pathway; negative regulation of smoothened signaling pathway; negative thymic T cell selection; positive regulation of alpha-beta T cell proliferation; positive regulation of calcium-mediated signaling; positive regulation of interferon-gamma production; positive regulation of interleukin-2 biosynthetic process; positive regulation of interleukin-4 production; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of T cell anergy; positive regulation of T cell proliferation; protein complex assembly; regulation of apoptosis; regulation of immune response; response to nutrient; signal complex assembly; T cell activation; T cell costimulation; T cell receptor signaling pathway; transmembrane receptor protein tyrosine kinase signaling pathway
Disease: Immunodeficiency 18
Reference #:  P07766 (UniProtKB)
Alt. Names/Synonyms: CD3-epsilon; CD3E; CD3E antigen, epsilon polypeptide; CD3e antigen, epsilon polypeptide (TiT3 complex); CD3e molecule, epsilon (CD3-TCR complex); CD3epsilon; FLJ18683; T-cell antigen receptor complex, epsilon subunit of T3; T-cell surface antigen T3/Leu-4 epsilon chain; T-cell surface glycoprotein CD3 epsilon chain; T3E; TCRE
Gene Symbols: CD3E
Molecular weight: 23,147 Da
Basal Isoelectric point: 6.32  Predict pI for various phosphorylation states
CST Pathways:  T Cell Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CD3E

Protein Structure Not Found.


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Sites Implicated In
molecular association, regulation: Y188‑p
phosphorylation: Y188‑p

Modification Sites and Domains  
Click here to view other types of protein modifications

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S77‑p EDDKNIGsDEDHLsL
0 1 S83‑p GsDEDHLsLKEFSEL
0 4 K177‑ub GRQRGQNkERPPPVP
4 384 Y188‑p PPVPNPDyEPIRKGQ
4 400 Y199‑p RKGQRDLysGLNQRR
0 19 S200‑p KGQRDLysGLNQRRI
  mouse

 
- gap
V68 QKHDKHLVLQDFSEV
K159‑ub SRPRGQNkERPPPVP
Y170‑p PPVPNPDyEPIRKGQ
Y181‑p RKGQRDLySGLNQRA
S182 KGQRDLySGLNQRAV
  rat

 
- gap
V63 DKNEKHLVLEDFSEV
K158 GKAQGQNKERPPPVP
Y169 PPVPNPDYEPIRKGQ
Y180 RKGQRDLYSGLNQRA
S181 KGQRDLYSGLNQRAV
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