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Protein Page:
NFAT4 (human)

Overview
NFAT4 a transcription factor that plays a role in the inducible expression of cytokine genes in T cells. Plays a role in the regulation of gene expression in T cells and immature thymocytes. Six spliced isoforms have been identified. Isoform 1 is predominantly expressed in thymus, peripheral blood leukocytes and kidney. Isoform 2 is predominantly expressed in skeletal muscle and is also found in thymus, kidney, testis, spleen, prostate, ovary, small intestine, heart, placenta and pancreas. Isoform 3 is expressed in thymus and kidney. Isoform 4 is expressed in thymus and skeletal muscle. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 16q22.2
Cellular Component: cytoplasm; cytosol; nucleolus; nucleoplasm; nucleus
Molecular Function: protein binding
Biological Process: inflammatory response; positive regulation of transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoter
Reference #:  Q12968 (UniProtKB)
Alt. Names/Synonyms: NF-AT4; NF-ATc3; NFAC3; NFAT4; NFATC3; NFATx; nuclear factor of activated T-cells c3 isoform IE-Xa; Nuclear factor of activated T-cells, cytoplasmic 3; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3; T cell transcription factor NFAT4; T-cell transcription factor NFAT4
Gene Symbols: NFATC3
Molecular weight: 115,594 Da
Basal Isoelectric point: 5.91  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  SAPK/JNK Signaling Cascades  |  T Cell Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

NFAT4

Protein Structure Not Found.
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Sites Implicated In
transcription, inhibited: S163‑p, S165‑p
intracellular localization: S163‑p, S165‑p, T204‑p, S207‑p, T210‑p, S211‑p, S215‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 S82‑p SPSFQLQsHKNyEGt
0 7 Y86‑p QLQsHKNyEGtCEIP
0 1 T89‑p sHKNyEGtCEIPESK
0 1 S98‑p EIPESKYsPLGGPKP
0 1 S117‑p SIQITSIsPNCHQEL
0 1 S145‑p REFLERPsRDHLyLP
0 7 Y150‑p RPsRDHLyLPLEPSY
0 1 S160 LEPSYRESSLsPsPA
1 2 S163‑p SYRESSLsPsPASSI
2 1 S165‑p RESSLsPsPASSISs
0 1 S172‑p sPASSISsRSWFsDA
1 0 S177‑p ISsRSWFsDAssCEs
1 0 S180‑p RSWFsDAssCEsLsH
1 0 S181‑p SWFsDAssCEsLsHI
1 0 S184‑p sDAssCEsLsHIYDD
1 0 S186‑p AssCEsLsHIYDDVD
1 0 T204‑p NEAAARFtLGsPLts
1 2 S207‑p AARFtLGsPLtsPGG
1 0 T210‑p FtLGsPLtsPGGsPG
1 2 S211‑p tLGsPLtsPGGsPGG
1 0 S215‑p PLtsPGGsPGGCPGE
0 1 S236‑p YGLGHSLsPRQSPCH
0 1 S247‑p SPCHSPRsSVTDENW
0 2 S261 WLSPRPASGPSsRPt
0 1 S264 PRPASGPSsRPtsPC
1 5 S265‑p RPASGPSsRPtsPCG
0 3 T268‑p SGPSsRPtsPCGKRR
0 13 S269‑p GPSsRPtsPCGKRRH
0 5 S277‑p PCGKRRHsSAEVCYA
0 2 S278 CGKRRHsSAEVCYAG
0 1 S286 AEVCYAGSLsPHHsP
0 2 S288‑p VCYAGSLsPHHsPVP
0 2 S292‑p GSLsPHHsPVPsPGH
0 1 S296‑p PHHsPVPsPGHsPRG
0 1 S300‑p PVPsPGHsPRGSVTE
0 1 T306 HsPRGSVTEDTWLNA
0 10 S344‑p PLKTRKTsEDQAAIL
0 6 S364‑p LCSDDQGsLsPAREt
0 16 S366‑p SDDQGsLsPAREtsI
0 1 T371‑p sLsPAREtsIDDGLG
0 2 S372‑p LsPAREtsIDDGLGS
0 1 T409 SKPKPGHTPIFRTss
0 1 S415‑p HTPIFRTssLPPLDW
0 5 S416‑p TPIFRTssLPPLDWP
0 1 T460 RGAVKASTGGHPVVK
0 8 S546‑p GILKLRNsDIELRKG
0 1 S730‑p PAQTQRPssDSGCSH
0 1 S731‑p AQTQRPssDSGCSHD
0 1 S742‑p CSHDSVLsGQRSLIC
0 3 Y884‑p PHLQSMGyHCSNTGQ
0 4 S1045‑p EIIGRDMsQIsVSQG
0 1 S1048‑p GRDMsQIsVSQGAGV
0 8 S1063‑p SRQAPLPsPEsLDLG
0 5 S1066‑p APLPsPEsLDLGRSD
  NFAT4 iso2  
S82 SPSFQLQSHKNYEGT
Y86 QLQSHKNYEGTCEIP
T89 SHKNYEGTCEIPESK
S98 EIPESKYSPLGGPKP
S117 SIQITSISPNCHQEL
S145 REFLERPSRDHLYLP
Y150 RPSRDHLYLPLEPSY
S160 LEPSYRESSLSPSPA
S163 SYRESSLSPSPASSI
S165 RESSLSPSPASSISS
S172 SPASSISSRSWFSDA
S177 ISSRSWFSDASSCES
S180 RSWFSDASSCESLSH
S181 SWFSDASSCESLSHI
S184 SDASSCESLSHIYDD
S186 ASSCESLSHIYDDVD
T204 NEAAARFTLGSPLTS
S207 AARFTLGSPLTSPGG
T210 FTLGSPLTSPGGSPG
S211 TLGSPLTSPGGSPGG
S215 PLTSPGGSPGGCPGE
S236 YGLGHSLSPRQSPCH
S247 SPCHSPRSSVTDENW
S261 WLSPRPASGPSSRPT
S264 PRPASGPSSRPTSPC
S265 RPASGPSSRPTSPCG
T268 SGPSSRPTSPCGKRR
S269 GPSSRPTSPCGKRRH
S277 PCGKRRHSSAEVCYA
S278 CGKRRHSSAEVCYAG
S286 AEVCYAGSLSPHHSP
S288 VCYAGSLSPHHSPVP
S292 GSLSPHHSPVPSPGH
S296 PHHSPVPSPGHSPRG
S300 PVPSPGHSPRGSVTE
T306 HSPRGSVTEDTWLNA
S344 PLKTRKTSEDQAAIL
S364 LCSDDQGSLSPARET
S366 SDDQGSLSPARETSI
T371 SLSPARETSIDDGLG
S372 LSPARETSIDDGLGS
T409 SKPKPGHTPIFRTSS
S415 HTPIFRTSSLPPLDW
S416 TPIFRTSSLPPLDWP
T460 RGAVKASTGGHPVVK
S546 GILKLRNSDIELRKG
S730 PAQTQRPSSDSGCSH
S731 AQTQRPSSDSGCSHD
S742 CSHDSVLSGQRSLIC
Y884 PHLQSMGYHCSNTGQ
- gap
- gap
- gap
- gap
  mouse

► Hide Isoforms
 
S82 SPSFQLQSHKNYEGT
Y86 QLQSHKNYEGTCEIP
T89 SHKNYEGTCEIPESK
S98 EIPESKYSPLGGPKP
S117 SIQFTSISPNCQQEL
S145 REFLERPSRDHLYLP
Y150 RPSRDHLYLPLEPSY
S160‑p LEPSYREsSLsPSPA
S163‑p SYREsSLsPSPASSI
S165 REsSLsPSPASSISS
S172 SPASSISSRSWFSDA
S177 ISSRSWFSDASSCES
S180 RSWFSDASSCESLSH
S181 SWFSDASSCESLSHI
S184 SDASSCESLSHIYDD
S186 ASSCESLSHIYDDVD
T204 NEAAARFTLGSPLTS
S207 AARFTLGSPLTSPGG
T210 FTLGSPLTSPGGSPG
S211 TLGSPLTSPGGSPGG
S215 PLTSPGGSPGGCPGE
S236 YGSGHSLSPRQSPCH
S247 SPCHSPRSSITDENW
S261‑p WLSPRPAsGPSSRPT
S264 PRPAsGPSSRPTsPC
S265 RPAsGPSSRPTsPCG
T268 sGPSSRPTsPCGKRR
S269‑p GPSSRPTsPCGKRRH
S277‑p PCGKRRHssAEVCYA
S278‑p CGKRRHssAEVCYAG
S286‑p AEVCYAGsLsPHHsP
S288‑p VCYAGsLsPHHsPVP
S292‑p GsLsPHHsPVPSPGH
S296 PHHsPVPSPGHSPRG
S300 PVPSPGHSPRGSVtE
T306‑p HSPRGSVtEDTWLTA
S344‑p PLKTRKTsEDQAAIL
N364 ICSDDQGNLsPSRET
S366‑p SDDQGNLsPSRETSV
T371 NLsPSRETSVDDGLG
S372 LsPSRETSVDDGLGS
T409 SKPKPGHTPIFRTSs
S415 HTPIFRTSsLPPLDW
S416‑p TPIFRTSsLPPLDWP
T460 RGAVKASTGGHPVVK
S546‑p GILKLRNsDIELRKG
S730 SAQAQRPSSETGHPH
S731 AQAQRPSSETGHPHD
S742 HPHDRAMSAPGGLLC
Y883 PHLQSMGYHCSNAGQ
S1044 EIIGRDMSQISVSQA
S1047 GRDMSQISVSQATEV
G1062 MRDTPLPGPAsPDLM
S1065‑p TPLPGPAsPDLMTSH
  NFAT4 iso3  
S82 SPSFQLQSHKNYEGT
Y86 QLQSHKNYEGTCEIP
T89 SHKNYEGTCEIPESK
S98 EIPESKYSPLGGPKP
S117 SIQFTSISPNCQQEL
S145 REFLERPSRDHLYLP
Y150 RPSRDHLYLPLEPSY
S160 LEPSYRESSLSPSPA
S163 SYRESSLSPSPASSI
S165 RESSLSPSPASSISS
S172 SPASSISSRSWFSDA
S177 ISSRSWFSDASSCES
S180 RSWFSDASSCESLSH
S181 SWFSDASSCESLSHI
S184 SDASSCESLSHIYDD
S186 ASSCESLSHIYDDVD
T204 NEAAARFTLGSPLTS
S207 AARFTLGSPLTSPGG
T210 FTLGSPLTSPGGSPG
S211 TLGSPLTSPGGSPGG
S215 PLTSPGGSPGGCPGE
S236 YGSGHSLSPRQSPCH
S247 SPCHSPRSSITDENW
S261 WLSPRPASGPSSRPT
S264 PRPASGPSSRPTSPC
S265 RPASGPSSRPTSPCG
T268 SGPSSRPTSPCGKRR
S269 GPSSRPTSPCGKRRH
S277 PCGKRRHSSAEVCYA
S278 CGKRRHSSAEVCYAG
S286 AEVCYAGSLSPHHSP
S288 VCYAGSLSPHHSPVP
S292 GSLSPHHSPVPSPGH
S296 PHHSPVPSPGHSPRG
S300 PVPSPGHSPRGSVTE
T306 HSPRGSVTEDTWLTA
S344 PLKTRKTSEDQAAIL
N364 ICSDDQGNLSPSRET
S366 SDDQGNLSPSRETSV
T371 NLSPSRETSVDDGLG
S372 LSPSRETSVDDGLGS
T409 SKPKPGHTPIFRTSS
S415 HTPIFRTSSLPPLDW
S416 TPIFRTSSLPPLDWP
T460‑p RGAVKAStGGHPVVK
S546 RVHIPQPSGKVLSLQ
S700 SAQAQRPSSETGHPH
S701 AQAQRPSSETGHPHD
S712 HPHDRAMSAPGGLLC
Y853 PHLQSMGYHCSNAGQ
S1014 EIIGRDMSQISVSQA
S1017 GRDMSQISVSQATEV
G1032 MRDTPLPGPASPDLM
S1035 TPLPGPASPDLMTSH
  rat

 
G83 SPSFQLQGFKNYEGT
Y87 QLQGFKNYEGTDDIS
T90 GFKNYEGTDDISESK
S99 DISESKYSSLSGPKP
S118 SIQITSISPNCHQET
S146 REYLERPSRDHLYLP
Y151 RPSRDHLYLPLEPSY
S161 LEPSYRESSLSPSPA
S164 SYRESSLSPSPASSV
S166 RESSLSPSPASSVSS
S173 SPASSVSSRSWFSDA
S178 VSSRSWFSDASSCES
S181 RSWFSDASSCESLSH
S182 SWFSDASSCESLSHI
S185 SDASSCESLSHIYDD
S187 ASSCESLSHIYDDVD
T205 NEAAARFTLGSPLTS
S208 AARFTLGSPLTSPGG
T211 FTLGSPLTSPGGSPG
S212 TLGSPLTSPGGSPGG
S216 PLTSPGGSPGGCPGE
S237 YGPGHSLSPRQSPCH
S248 SPCHSPRSSITDENW
S262‑p WLSPRPAsGPssRPt
S265‑p PRPAsGPssRPtsPC
S266‑p RPAsGPssRPtsPCG
T269‑p sGPssRPtsPCGKRR
S270‑p GPssRPtsPCGKRRH
S278 PCGKRRHSSAEVCYA
S279 CGKRRHSSAEVCYAG
S287 AEVCYAGSLSPHHSP
S289 VCYAGSLSPHHSPVP
S293 GSLSPHHSPVPSPGH
S297 PHHSPVPSPGHSPRG
S301 PVPSPGHSPRGSVTE
T307 HSPRGSVTEDTWLTA
S345 PLKTRKTSDDQAAIL
S365 VCSDDQGSLSPSRET
S367 SDDQGSLSPSRETSV
T372 SLSPSRETSVDDGLG
S373 LSPSRETSVDDGLGS
T410‑p SKPKPGHtPIFRTSS
S416 HtPIFRTSSLPPLDW
S417 tPIFRTSSLPPLDWP
T461 RGAVKASTGGHPVVK
S547 GILKLRNSDIELRKG
S731 SAQTQRPSSDTGHPH
S732 AQTQRPSSDTGHPHD
S743 HPHDSALSAPRSLIC
Y884 PHLQSMGYHCSSAGQ
- gap
- gap
- gap
- gap
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