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Protein Page:
VEGF (human)

Overview
VEGF Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth. Defects in VEGFA are a cause of susceptibility to microvascular complications of diabetes type 1 (MVCD1). These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. Belongs to the PDGF/VEGF growth factor family. 13 isoforms of the human protein are produced by alternative promoter. Note: This description may include information from UniProtKB.
Protein type: Cytokine; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 6p12
Cellular Component: cell surface; cytoplasm; extracellular region; extracellular space; secretory granule
Molecular Function: chemoattractant activity; cytokine activity; extracellular matrix binding; fibronectin binding; growth factor activity; heparin binding; identical protein binding; platelet-derived growth factor receptor binding; protein binding; protein heterodimerization activity; protein homodimerization activity; receptor agonist activity; vascular endothelial growth factor receptor 1 binding; vascular endothelial growth factor receptor 2 binding; vascular endothelial growth factor receptor binding
Biological Process: activation of CREB transcription factor; activation of protein kinase activity; angiogenesis; artery morphogenesis; branching morphogenesis of a tube; camera-type eye morphogenesis; cardiac muscle fiber development; cell maturation; cell migration during sprouting angiogenesis; epithelial cell differentiation; eye photoreceptor cell development; growth; heart morphogenesis; in utero embryonic development; kidney development; lactation; lumen formation; lung development; macrophage differentiation; mesoderm development; monocyte differentiation; negative regulation of apoptosis; negative regulation of caspase activity; negative regulation of transcription from RNA polymerase II promoter; nervous system development; ovarian follicle development; patterning of blood vessels; platelet degranulation; positive chemotaxis; positive regulation of angiogenesis; positive regulation of axon extension involved in axon guidance; positive regulation of blood vessel endothelial cell migration; positive regulation of cell adhesion; positive regulation of cell migration; positive regulation of cell motility; positive regulation of cell proliferation; positive regulation of endothelial cell proliferation; positive regulation of epithelial cell proliferation; positive regulation of focal adhesion formation; positive regulation of leukocyte migration; positive regulation of MAP kinase activity; positive regulation of mesenchymal cell proliferation; positive regulation of neuroblast proliferation; positive regulation of peptidyl-serine phosphorylation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of positive chemotaxis; positive regulation of protein amino acid autophosphorylation; positive regulation of protein amino acid phosphorylation; positive regulation of protein complex assembly; positive regulation of receptor internalization; positive regulation of transcription from RNA polymerase II promoter; positive regulation of tyrosine phosphorylation of Stat3 protein; positive regulation of vascular endothelial growth factor receptor signaling pathway; post-embryonic camera-type eye development; regulation of cell shape; regulation of cGMP metabolic process; response to hypoxia; surfactant homeostasis; vascular endothelial growth factor receptor signaling pathway; vasculogenesis
Disease: Microvascular Complications Of Diabetes, Susceptibility To, 1
Reference #:  P15692 (UniProtKB)
Alt. Names/Synonyms: Vascular endothelial growth factor A; Vascular permeability factor; VEGF-A; VEGFA
Gene Symbols: VEGFA
Molecular weight: 27,042 Da
Basal Isoelectric point: 9.21  Predict pI for various phosphorylation states
CST Pathways:  Angiogenesis
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VEGF

Protein Structure Not Found.
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