a proto-oncogenic guanine nucleotide exchange factors (GEF) of the Dbl family. A GEF for the Rho family of GTP binding proteins. Expressed in most tissues. Note: This description may include information from UniProtKB.
Protein type: GEFs; GEFs, Rac/Rho; Motility/polarity/chemotaxis
Molecular Function: epidermal growth factor receptor binding; guanyl-nucleotide exchange factor activity; metal ion binding; protein binding; Rho guanyl-nucleotide exchange factor activity
Biological Process: angiogenesis; cell migration; ephrin receptor signaling pathway; lamellipodium biogenesis; platelet activation; positive regulation of apoptosis; positive regulation of GTPase activity; positive regulation of phosphoinositide 3-kinase activity; regulation of blood coagulation; regulation of cell size; regulation of gene expression; regulation of GTPase activity; regulation of Rho protein signal transduction; regulation of small GTPase mediated signal transduction; signal transduction; small GTPase mediated signal transduction; vascular endothelial growth factor receptor signaling pathway
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.