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Protein Page:
YAP1 (human)

YAP1 an adaptor protein that binds to HER4 and the SH3 domain of the Yes tyrosine kinase. Associates with multiple transcription factors in the nucleus, and appears to be a co-transcriptional activator for the carboxyl-terminal fragment of ErbB-4 that translocates to the nucleus. Contains a WW domain that is found in various structural, regulatory and signaling molecules. Note: This description may include information from UniProtKB.
Protein type: Oncoprotein; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 11q22.1
Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus
Molecular Function: protein binding; protein heterodimerization activity; transcription activator binding; transcription coactivator activity; transcription corepressor activity
Biological Process: cell proliferation; positive regulation of transcription, DNA-dependent; protein complex assembly; regulation of neurogenesis; response to DNA damage stimulus; transcription initiation from RNA polymerase II promoter
Disease: Coloboma, Ocular, With Or Without Hearing Impairment, Cleft Lip/palate, And/or Mental Retardation
Reference #:  P46937 (UniProtKB)
Alt. Names/Synonyms: 65 kDa Yes-associated protein; YAP; YAP1; YAP2; YAP65; Yes-associated protein 1; Yes-associated protein 1, 65kDa; yes-associated protein 2; YKI; Yorkie homolog
Gene Symbols: YAP1
Molecular weight: 54,462 Da
Basal Isoelectric point: Predict pI for various phosphorylation states
CST Pathways:  Hippo Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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