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Protein Page:
BAFF (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
BAFF Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response. Belongs to the tumor necrosis factor family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; Apoptosis; Membrane protein, integral; Cytokine
Chromosomal Location of Human Ortholog: 13q32-q34
Cellular Component: cytoplasm; extracellular region; perinuclear region of cytoplasm
Molecular Function: protein binding; receptor binding
Biological Process: cell proliferation; positive regulation of B cell proliferation; positive regulation of cell proliferation; signal transduction; tumor necrosis factor-mediated signaling pathway
Reference #:  Q9Y275 (UniProtKB)
Alt. Names/Synonyms: ApoL related ligand TALL-1; B lymphocyte stimulator; B-cell activating factor; B-cell-activating factor; B-lymphocyte stimulator; BAFF; BLYS; CD257; delta BAFF; Dendritic cell-derived TNF-like molecule; DTL; TALL-1; TALL1; THANK; TN13B; TNF and ApoL-related leukocyte expressed ligand 1; TNF homolog that activates apoptosis; TNF- and APOL-related leukocyte expressed ligand 1; TNFSF13B; TNFSF20; tumor necrosis factor (ligand) superfamily, member 13b; tumor necrosis factor (ligand) superfamily, member 20; Tumor necrosis factor ligand superfamily member 13B; Tumor necrosis factor ligand superfamily member 13b, membrane form; Tumor necrosis factor ligand superfamily member 13b, soluble form; tumor necrosis factor superfamily, member 13b; tumor necrosis factor-like protein ZTNF4; ZTNF4
Gene Symbols: TNFSF13B
Molecular weight: 31,223 Da
Basal Isoelectric point: 5.92  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

BAFF

Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S41‑p KESPSVRsSKDGKLL
0 1 C60 LLALLSCCLTVVSFY
0 1 T62 ALLSCCLTVVSFYQV
0 1 K184‑ac ALEEKENkILVKETG
0 1 K204‑ac GQVLYTDkTYAMGHL
  mouse

 
I42 EEGAWFGICRDGRLL
S61‑p LLALLSSsFtAMSLY
T63‑p ALLSSsFtAMSLYQL
K208 ALEEKENKIVVRQTG
P228 SQVLYTDPIFAMGHV
  rat

 
I57 KEGAWVGICRDRRLL
S76 LLALLSSSFTAMSLY
T78 ALLSSSFTAMSLYQL
- gap
- gap
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