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Protein Page:
BAFF (human)
rdtyret
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
BAFF Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response. Belongs to the tumor necrosis factor family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Apoptosis; Cell cycle regulation; Cytokine
Chromosomal Location of Human Ortholog: 13q32-q34
Cellular Component: cytoplasm; extracellular region; extracellular space; integral to membrane; perinuclear region of cytoplasm; plasma membrane
Molecular Function: cytokine activity; protein binding; receptor binding; tumor necrosis factor receptor binding
Biological Process: B cell costimulation; B cell homeostasis; cell proliferation; immune response; immunoglobulin secretion; positive regulation of B cell proliferation; positive regulation of cell proliferation; positive regulation of germinal center formation; positive regulation of T cell proliferation; signal transduction; T cell costimulation; tumor necrosis factor-mediated signaling pathway
Reference #:  Q9Y275 (UniProtKB)
Alt. Names/Synonyms: ApoL related ligand TALL-1; B lymphocyte stimulator; B-cell activating factor; B-cell-activating factor; B-lymphocyte stimulator; BAFF; BLYS; CD257; delta BAFF; Dendritic cell-derived TNF-like molecule; DTL; TALL-1; TALL1; THANK; TN13B; TNF and ApoL-related leukocyte expressed ligand 1; TNF homolog that activates apoptosis; TNF- and APOL-related leukocyte expressed ligand 1; TNFSF13B; TNFSF20; tumor necrosis factor (ligand) superfamily, member 13b; tumor necrosis factor (ligand) superfamily, member 20; Tumor necrosis factor ligand superfamily member 13B; Tumor necrosis factor ligand superfamily member 13b, membrane form; Tumor necrosis factor ligand superfamily member 13b, soluble form; tumor necrosis factor superfamily, member 13b; tumor necrosis factor-like protein ZTNF4; ZTNF4
Gene Symbols: TNFSF13B
Molecular weight: 31,223 Da
Basal Isoelectric point: 5.92  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

BAFF

Protein Structure Not Found.


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Modification Sites and Domains  
Click here to view other types of protein modifications

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S41‑p KESPSVRsSKDGKLL
0 1 C60 LLALLSCCLTVVSFY
0 1 T62 ALLSCCLTVVSFYQV
0 1 K184‑ac ALEEKENkILVKETG
0 1 K204‑ac GQVLYTDkTYAMGHL
  mouse

 
I42 EEGAWFGICRDGRLL
S61‑p LLALLSSsFtAMSLY
T63‑p ALLSSsFtAMSLYQL
K208 ALEEKENKIVVRQTG
P228 SQVLYTDPIFAMGHV
  rat

 
I57 KEGAWVGICRDRRLL
S76 LLALLSSSFTAMSLY
T78 ALLSSSFTAMSLYQL
- gap
- gap
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