a histone acetyl transferase (HAT) of the MYST family. Originally isolated as an HIV-1 TAT-interactive protein. Plays an important role in regulating chromatin remodeling, transcription and other nuclear processes by acetylating nuclear proteins. Plays a role in DNA repair and apoptosis. Three splice variants have been described.. Note: This description may include information from UniProtKB.
Protein type: EC 22.214.171.124; Nucleolus; Acetyltransferase; Nuclear receptor co-regulator
Cellular Component: NuA4 histone acetyltransferase complex; nucleolus; nucleoplasm; nucleus; perinuclear region of cytoplasm; transcription factor complex
Molecular Function: acetyltransferase activity; androgen receptor binding; histone acetyltransferase activity; metal ion binding; protein binding; transcription coactivator activity
Biological Process: androgen receptor signaling pathway; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; DNA repair; double-strand break repair; double-strand break repair via homologous recombination; double-strand break repair via nonhomologous end joining; double-strand break repair via synthesis-dependent strand annealing; establishment and/or maintenance of chromatin architecture; histone acetylation; negative regulation of interleukin-2 production; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; proteasomal ubiquitin-dependent protein catabolic process; regulation of growth; response to ionizing radiation; transcription, DNA-dependent; viral reproduction
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.