a S/T protein kinase of the STE20 family. Mst kinases regulate processes such as apoptosis, morphogenesis, and cytoskeletal rearrangements, and are upstream activators of MAPK pathways that. The amino-terminal kinase domain of Mst is considerably homologous to the kinase domain of yeast STE20 kinase and other p21-activated kinases. otential mediator of cell growth. Interaction with Golgi matrix protein GOLGA2 leads to autophosphorylation on Thr-178, possibly as a consequence of stabilization of dimer formation. May also be activated by C-terminal cleavage. Note: This description may include information from UniProtKB.
Protein type: Kinase, protein; Protein kinase, STE; EC 18.104.22.168; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family; YSK subfamily
Cellular Component: apical plasma membrane; centrosome; cytoplasm; cytosol; Golgi apparatus; Golgi membrane; Golgi-associated vesicle; nucleus; perinuclear region of cytoplasm
Molecular Function: ATP binding; identical protein binding; magnesium ion binding; protein binding; protein homodimerization activity; protein kinase activity; protein serine/threonine kinase activity; Rac GTPase binding
Biological Process: actin cytoskeleton organization and biogenesis; activation of protein kinase activity; apoptosis; cell migration; cell structure disassembly during apoptosis; microvillus biogenesis; programmed cell death; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of apoptosis; regulation of MAPKKK cascade; regulation of mitotic cell cycle; response to hydrogen peroxide; Rho protein signal transduction; stress-activated protein kinase signaling pathway
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.