a S/T protein kinase of the STE20 family. Mst kinases regulate processes such as apoptosis, morphogenesis, and cytoskeletal rearrangements, and are upstream activators of MAPK pathways that. The amino-terminal kinase domain of Mst is considerably homologous to the kinase domain of yeast STE20 kinase and other p21-activated kinases. otential mediator of cell growth. Interaction with Golgi matrix protein GOLGA2 leads to autophosphorylation on Thr-178, possibly as a consequence of stabilization of dimer formation. May also be activated by C-terminal cleavage. Note: This description may include information from UniProtKB.
Protein type: EC 126.96.36.199; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family; YSK subfamily
Cellular Component: apical plasma membrane; cytoplasm; cytosol; Golgi apparatus; Golgi-associated vesicle; membrane; perinuclear region of cytoplasm; vesicle membrane
Molecular Function: ATP binding; identical protein binding; magnesium ion binding; MAP kinase kinase kinase kinase activity; protein binding; protein homodimerization activity; protein kinase activity
Biological Process: cellular response to starvation; microvillus biogenesis; negative regulation of cell migration; neurite morphogenesis; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of apoptosis; regulation of mitotic cell cycle; response to hydrogen peroxide; stress-activated protein kinase signaling pathway