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Protein Page:
INDO (human)
rdtyret
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
INDO Catalyzes the cleavage of the pyrrol ring of tryptophan and incorporates both atoms of a molecule of oxygen. Belongs to the indoleamine 2,3-dioxygenase family. Note: This description may include information from UniProtKB.
Protein type: Oxidoreductase; EC 1.13.11.52; Amino Acid Metabolism - tryptophan; Cell cycle regulation
Chromosomal Location of Human Ortholog: 8p12-p11
Cellular Component: cytosol; smooth muscle contractile fiber; stereocilium bundle
Molecular Function: electron carrier activity; heme binding; indoleamine 2,3-dioxygenase activity; metal ion binding; tryptophan 2,3-dioxygenase activity
Biological Process: cytokine production during acute inflammatory response; female pregnancy; immune system process; multicellular organismal response to stress; negative regulation of interleukin-10 production; negative regulation of T cell proliferation; positive regulation of chronic inflammatory response; positive regulation of interleukin-12 production; positive regulation of T cell tolerance induction; positive regulation of T-helper 2 type immune response; regulation of activated T cell proliferation; response to lipopolysaccharide; tryptophan catabolic process; tryptophan catabolic process to kynurenine
Reference #:  P14902 (UniProtKB)
Alt. Names/Synonyms: I23O1; IDO; IDO-1; IDO1; INDO; indole 2,3-dioxygenase; Indoleamine 2,3-dioxygenase 1; indoleamine-pyrrole 2,3 dioxygenase; Indoleamine-pyrrole 2,3-dioxygenase
Gene Symbols: IDO1
Molecular weight: 45,326 Da
Basal Isoelectric point: 6.87  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

INDO

Protein Structure Not Found.


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Modification Sites and Domains  
Click here to view other types of protein modifications

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 0 Y111 PRNIAVPYCQLSKKL
0 1 L211 ASCLEKALQVFHQIH
1 0 Y249 QLSDGLVYEGFWEDP
0 1 Y332‑p DAGLREAyDACVKAL
0 1 S372‑p NKTSEDPsKLEAKGT
0 1 T390‑p DLMNFLKtVRSTTEK
  mouse

 
Y115‑p PRNIAVPyCELSEKL
K215 ATSLEKAKEIFKRMR
Y253‑p KLPEGLLyEGVWDTP
Y336 NEDLTKAYNECVNGL
S376 GDKSEEPSNVESRGT
S394 NPMTFLRSVKDTTEK
  rat

 
Y115 PRNLAVPYCELSEKL
K215‑ac AASLEKAkEIFKRMR
Y253 KLPEGLLYEGVWDTP
Y336 NEDLKEAYNECVNGL
S376 GHKSEEPSNTENRGT
S394 DVMNFLRSVKDTTKK
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