Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Protein Page:
HES1 (human)
rdtyret
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
HES1 Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity. May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Cell development/differentiation; Transcription factor
Chromosomal Location of Human Ortholog: 3q28-q29
Cellular Component: cytoplasm; nucleoplasm; nucleus
Molecular Function: chaperone binding; DNA binding; histone deacetylase binding; protein binding; protein homodimerization activity; sequence-specific DNA binding; transcription factor activity; transcription factor binding
Biological Process: adenohypophysis development; artery morphogenesis; auditory receptor cell fate determination; cell adhesion; cell maturation; cell migration; endocrine pancreas development; hindbrain morphogenesis; lateral inhibition; liver development; lung development; midbrain development; midbrain-hindbrain boundary morphogenesis; negative regulation of auditory receptor cell differentiation; negative regulation of oligodendrocyte differentiation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; nervous system development; neuron morphogenesis during differentiation; Notch signaling pathway; oculomotor nerve development; positive regulation of astrocyte differentiation; positive regulation of BMP signaling pathway; positive regulation of cell proliferation; positive regulation of DNA binding; positive regulation of JAK-STAT cascade; positive regulation of mitotic cell cycle, embryonic; positive regulation of Notch signaling pathway; positive regulation of T cell proliferation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of tyrosine phosphorylation of Stat3 protein; protein complex assembly; radial glial cell differentiation in the forebrain; regulation of fat cell differentiation; regulation of timing of neuron differentiation; smoothened signaling pathway; somatic stem cell maintenance; STAT protein nuclear translocation; telencephalon development; thymus development; transcription, DNA-dependent; trochlear nerve development
Reference #:  Q14469 (UniProtKB)
Alt. Names/Synonyms: BHLHB39; Class B basic helix-loop-helix protein 39; FLJ20408; Hairy and enhancer of split 1; hairy and enhancer of split 1, (Drosophila); Hairy homolog; Hairy-like protein; HES-1; HES1; hHL; HL; HRY; Transcription factor HES-1
Gene Symbols: HES1
Molecular weight: 29,541 Da
Basal Isoelectric point: 9.66  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

HES1

Protein Structure Not Found.


STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Sites Implicated In
cytoskeletal reorganization: S37‑p, S38‑p
transcription, altered: S37‑p, S38‑p
molecular association, regulation: S37‑p, S38‑p

Modification Sites and Domains  
Click here to view other types of protein modifications

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S10‑p ADIMEKNsssPVAAT
0 1 S11‑p DIMEKNsssPVAATP
0 1 S12‑p IMEKNsssPVAATPA
0 2 T24‑p TPASVNTtPDKPKTA
0 2 S32‑p PDKPKTAsEHRKssK
1 0 S37‑p TAsEHRKssKPIMEK
1 1 S38‑p AsEHRKssKPIMEKR
0 1 S55‑p ARINESLsQLKtLIL
0 1 T59‑p ESLsQLKtLILDALK
0 1 K86‑ub DILEMTVkHLRNLQR
0 1 T97‑p NLQRAQMtAALSTDP
0 1 K109‑ub TDPSVLGkYRAGFSE
1 0 S262 SVGPNAVSPSSGPSL
  mouse

 
S10 ADIMEKNSSsPVAAT
S11 DIMEKNSSsPVAATP
S12 IMEKNSSSPVAATPA
T24 TPASVNTTPDKPKTA
S32 PDKPKTASEHRKSSK
S37 TASEHRKSSKPIMEK
S38 ASEHRKSSKPIMEKR
S55 ARINESLSQLKTLIL
T59 ESLSQLKTLILDALK
K86 DILEMTVKHLRNLQR
T97 NLQRAQMTAALSTDP
K109 TDPSVLGKYRAGFSE
S264 SVGPNAVSPSSGSSL
  rat

 
S10 ADIMEKNSSSPVAAT
S11 DIMEKNSSSPVAATP
S12 IMEKNSSSPVAATPA
T24 TPASVNTTPDKPKTA
S32 PDKPKTASEHRKSSK
S37 TASEHRKSSKPIMEK
S38 ASEHRKSSKPIMEKR
S55 ARINESLSQLKTLIL
T59 ESLSQLKTLILDALK
K86 DILEMTVKHLRNLQR
T97 NLQRAQMTAALSTDP
K109 TDPSVLGKYRAGFSE
S263‑p SVGPNAVsPSSGSSL
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.