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Protein Page:
GZMB (human)

Overview
GZMB This enzyme is necessary for target cell lysis in cell- mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis. By staphylococcal enterotoxin A (SEA) in peripheral blood leukocytes. Inactivated by the serine protease inhibitor diisopropylfluorophosphate. Belongs to the peptidase S1 family. Granzyme subfamily. Note: This description may include information from UniProtKB.
Protein type: Protease; EC 3.4.21.79; Apoptosis
Chromosomal Location of Human Ortholog: 14q11.2
Cellular Component: cytoplasm; cytosol; immunological synapse; intracellular membrane-bound organelle; membrane; mitochondrion; nucleus
Molecular Function: protein binding; serine-type endopeptidase activity; serine-type peptidase activity
Biological Process: apoptosis; cytolysis; induction of apoptosis by granzyme; natural killer cell mediated cytotoxicity; Notch signaling pathway; programmed cell death; protein processing; T cell mediated cytotoxicity
Reference #:  P10144 (UniProtKB)
Alt. Names/Synonyms: C11; Cathepsin G-like 1; CCPI; CGL-1; CGL1; CSP-B; CSPB; CTLA-1; CTLA1; CTSGL1; cytotoxic serine protease B; Cytotoxic T-lymphocyte proteinase 2; fragmentin 2; Fragmentin-2; GRAB; Granzyme B; granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1); Granzyme-2; GRB; GZMB; HLP; Human lymphocyte protein; Lymphocyte protease; SECT; T-cell serine protease 1-3E
Gene Symbols: GZMB
Molecular weight: 27,716 Da
Basal Isoelectric point: 9.62  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

GZMB

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T150‑p SVAGWGQtAPLGKHS
  mouse

 
M150 YVAGWGRMAPMGKYS
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