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Protein Page:
FOXP2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
FOXP2 Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Involved in neural mechanisms mediating the development of speech and language. Forms homodimers and heterodimers with FOXP1 and FOXP4. Dimerization is required for DNA-binding. Interacts with CTBP1. Isoform 1 and isoform 6 are expressed in adult and fetal brain, caudate nucleus and lung. 9 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; C2H2-type zinc finger protein
Chromosomal Location of Human Ortholog: 7q31
Cellular Component: nucleus
Molecular Function: DNA binding; protein binding; protein homodimerization activity; sequence-specific DNA binding; transcription factor activity
Biological Process: caudate nucleus development; cerebral cortex development; negative regulation of transcription, DNA-dependent; putamen development
Disease: Speech-language Disorder 1
Reference #:  O15409 (UniProtKB)
Alt. Names/Synonyms: CAG repeat protein 44; CAGH44; DKFZp686H1726; forkhead box P2; Forkhead box protein P2; forkhead/winged-helix transcription factor; FOXP2; SPCH1; TNRC10; trinucleotide repeat containing 10; Trinucleotide repeat-containing gene 10 protein
Gene Symbols: FOXP2
Molecular weight: 79,919 Da
Basal Isoelectric point: 6.06  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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FOXP2

Protein Structure Not Found.
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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S71‑p LLLQQQTsGLKSPKS
0 2 S308‑p SSNTSKAsPPITHHS
0 1 K421 SEPKPSPKPLNLVSS
0 1 Y540‑p WFTRTFAyFRRNAAT
0 1 Y580‑p WTVDEVEyQKRRSQK
0 2 S591‑p RSQKITGsPTLVKNI
1 0 K674 HIHSIHVKEEPVIAE
0 1 S688 EDEDCPMSLVTTANH
0 2 S711 EIEEEPLSEDLE___
  mouse

 
S71 LLLQQQTSGLKSPKS
S307 SSTTSKASPPITHHS
K420 SEPKPSPKPLNLVSS
Y539 WFTRTFAYFRRNAAT
Y579 WTVDEVEYQKRRSQK
S590 RSQKITGSPTLVKNI
K673‑sm HIHSIHVkEEPVIAE
S687‑p EDEDCPMsLVTTANH
S710‑p EIEEEPLsEDLE___
  rat

 
S71 LLLQQQTSGLKSPKS
S329 SSTTSKASPPITHHS
K442‑ub SEPKPSPkPLNLVSS
Y561 WFTRTFAYFRRNAAT
Y601 WTVDEVEYQKRRSQK
S612 RSQKITGSPTLVKNI
K695 HIHSIHVKEEPVIAE
S709 EDEDCPMSLVTTANH
S732 EIEEEPLSEDLE___
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