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Protein Page:
EFNB3 (human)

EFNB3 Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. May play a pivotal role in forebrain function. Binds to, and induce the collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons. Belongs to the ephrin family. Note: This description may include information from UniProtKB.
Protein type: Cell development/differentiation; Ligand, receptor tyrosine kinase; Membrane protein, integral
Chromosomal Location of Human Ortholog: 17p13.1
Cellular Component: integral to plasma membrane; plasma membrane
Molecular Function: ephrin receptor binding; transmembrane-ephrin receptor activity
Biological Process: axon guidance; cell-cell signaling; ephrin receptor signaling pathway; nervous system development
Reference #:  Q15768 (UniProtKB)
Alt. Names/Synonyms: EFL6; EFNB3; EPH-related receptor transmembrane ligand ELK-L3; EPH-related receptor tyrosine kinase ligand 8; Ephrin B3; Ephrin-B3; EPLG8; LERK-8; LERK8
Gene Symbols: EFNB3
Molecular weight: 35,835 Da
Basal Isoelectric point: 8.85  Predict pI for various phosphorylation states
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Protein Structure Not Found.
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