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Protein Page:
DBH (human)

Overview
DBH Conversion of dopamine to noradrenaline. Homotetramer composed of two non-covalently bound disulfide-linked dimers. Activity is enhanced by nerve growth factor (in superior cervical ganglia and adrenal medulla). Trans-synaptic stimulation with reserpine, acetylcholine and glucocorticoids. Belongs to the copper type II ascorbate-dependent monooxygenase family. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Amino Acid Metabolism - tyrosine; EC 1.14.17.1; Apoptosis; Oxidoreductase; Membrane protein, integral; Cell cycle regulation
Chromosomal Location of Human Ortholog: 9q34
Cellular Component: cytoplasm; extracellular region; integral to membrane; membrane
Molecular Function: catalytic activity; copper ion binding; dopamine beta-monooxygenase activity; L-ascorbic acid binding
Biological Process: behavioral response to ethanol; blood vessel remodeling; catecholamine biosynthetic process; cytokine production; dopamine catabolic process; fear response; glucose homeostasis; homoiothermy; leukocyte mediated immunity; leukocyte migration; locomotory behavior; maternal behavior; memory; norepinephrine biosynthetic process; positive regulation of vasoconstriction; regulation of cell proliferation; response to amphetamine; response to pain; synaptic transmission; visual learning
Disease: Dopamine Beta-hydroxylase Deficiency, Congenital
Reference #:  P09172 (UniProtKB)
Gene Symbols: DBH
Molecular weight: 69,065 Da
Basal Isoelectric point: 5.97  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

DBH

Protein Structure Not Found.
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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 3 Y310‑p ALGAKAFyYPEEAGL
0 1 Y327‑p GGPGSSRyLRLEVHy
0 1 Y334‑p yLRLEVHyHNPLVIE
0 1 Y353‑p SSGIRLYyTAKLRRF
0 1 T422‑p LTGRKVVtVLVRDGR
0 1 S587‑p QPLPKVIstLEEPTP
0 1 T588‑p PLPKVIstLEEPTPQ
0 1 S603‑p CPTSQGRsPAGPTVV
  mouse

 
Y314 ALGAKAFYYPKEAGV
F331 GGPGSSPFLRLEVHY
Y338 FLRLEVHYHNPRKIQ
Y357 SSGIRLHYTATLRRY
T426 LTGRKVVTVLARDGQ
S591 QPLPKITSTLEEPTP
T592 PLPKITSTLEEPTPR
S607 CPIRQTQSPANPTVP
  rat

 
Y313 ALGAKAFYYPEEAGV
F330 GSSGSSRFLRLEVHY
Y337 FLRLEVHYHNPRNIQ
Y356 SSGIRLHYTASLRPN
T425 LTGRKVITVLARDGQ
S590 QPLPNITSAVEEPDP
A591 PLPNITSAVEEPDPR
G606 CPIRQTRGPAGPFVV
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