Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
HomeAbout PhosphoSiteUsing PhosphoSiteprivacy & cookiesCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Protein Page:
HSL (human)

HSL hormone sensitive lipase is a lipolytic enzyme of the 'GDXG' family. Plays a rate limiting step in triglyceride lipolysis. In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production. Rapidly activated by cAMP-dependent phosphorylation under the influence of catecholamines. Dephosphorylation and inactivation are controlled by insulin. Note: This description may include information from UniProtKB.
Protein type: EC; Lipase
Chromosomal Location of Human Ortholog: 19q13.2
Cellular Component: lipid particle
Molecular Function: protein binding
Biological Process: lipid catabolic process; protein amino acid phosphorylation
Disease: Abdominal Obesity-metabolic Syndrome 4
Reference #:  Q05469 (UniProtKB)
Alt. Names/Synonyms: Hormone-sensitive lipase; hormone-sensitive lipase testicular isoform; HSL; LHS; lipase, hormone-sensitive; LIPE; LIPS
Gene Symbols: LIPE
Molecular weight: 116,598 Da
Basal Isoelectric point: 6.25  Predict pI for various phosphorylation states
CST Pathways:  AMPK Signaling  |  Insulin Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene