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Protein Page:
GMCSF (human)

Overview
GMCSF Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. Belongs to the GM-CSF family. Note: This description may include information from UniProtKB.
Protein type: Cytokine; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 5q31.1
Cellular Component: extracellular region; extracellular space; intracellular
Molecular Function: cytokine activity; granulocyte macrophage colony-stimulating factor receptor binding; growth factor activity; protein binding; protein-tyrosine kinase activity; Ras guanyl-nucleotide exchange factor activity
Biological Process: embryonic placenta development; epithelial fluid transport; immune response; macrophage activation; MAPKKK cascade; myeloid dendritic cell differentiation; negative regulation of cytolysis; peptidyl-tyrosine phosphorylation; positive regulation of cell proliferation; positive regulation of DNA replication; positive regulation of GTPase activity; positive regulation of interleukin-23 production; positive regulation of tyrosine phosphorylation of Stat5 protein
Reference #:  P04141 (UniProtKB)
Alt. Names/Synonyms: colony stimulating factor 2 (granulocyte-macrophage); Colony-stimulating factor; CSF; CSF2; GM-CSF; GMCSF; granulocyte-macrophage colony stimulating factor; Granulocyte-macrophage colony-stimulating factor; MGC131935; MGC138897; Molgramostin; Sargramostim
Gene Symbols: CSF2
Molecular weight: 16,295 Da
Basal Isoelectric point: 5.21  Predict pI for various phosphorylation states
Select Structure to View Below

GMCSF

Protein Structure Not Found.
Download PyMol Script
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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S86‑p YKQGLRGsLTKLKGP
0 1 T95‑p TKLKGPLtMMASHYK
0 1 T119‑p SCATQIItFESFKEN
  mouse

 
N83 FEQGLRGNFTKLKGA
N92 TKLKGALNMTASYYQ
T116 DCETQVTTYADFIDS
  rat

 
N86 YKQGLRGNLTKLNGA
T95 TKLNGALTMIASHYQ
T119 DCEIEVTTFEDFIKN
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