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Protein Page:
CD209 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CD209 Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. Thought to mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. The receptor returns to the cell membrane surface and the pathogen-derived antigens are presented to resting T-cells via MHC class II proteins to initiate the adaptive immune response. Probably recognizes in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens, including HIV-1 gp120, HIV-2 gp120, SIV gp120, ebolavirus glycoproteins, cytomegalovirus gB, HCV E2, dengue virus gE, Leishmania pifanoi LPG, Lewis-x antigen in Helicobacter pylori LPS, mannose in Klebsiella pneumonae LPS, di-mannose and tri- mannose in Mycobacterium tuberculosis ManLAM and Lewis-x antigen in Schistosoma mansoni SEA. Homotetramer. Binds to many viral surface glycoproteins such as HIV-1 gp120, HIV-2 gp120, SIV gp120, ebolavirus envelope glycoproteins, cytomegalovirus gB, HCV E2 and dengue virus major envelope protein E. Predominantly expressed in dendritic cells and in DC-residing tissues. Also found in placental macrophages, endothelial cells of placental vascular channels, peripheral blood mononuclear cells, and THP-1 monocytes. 13 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 19p13
Cellular Component: cell surface; membrane; plasma membrane
Molecular Function: mannose binding; protein binding; virion binding
Biological Process: cell-cell recognition; heterophilic cell adhesion; regulation of T cell proliferation; stimulatory C-type lectin receptor signaling pathway; virion attachment to host cell surface receptor; virus-host interaction
Disease: Human Immunodeficiency Virus Type 1, Susceptibility To; Mycobacterium Tuberculosis, Susceptibility To
Reference #:  Q9NNX6 (UniProtKB)
Alt. Names/Synonyms: C-type lectin domain family 4 member L; C-type lectin domain family 4, member L; CD209; CD209 antigen; CD209 molecule; CDSIGN; CLEC4L; DC-SIGN; DC-SIGN1; Dendritic cell-specific ICAM-3-grabbing non-integrin 1; dendritic cell-specific intracellular adhesion molecules (ICAM)-3 grabbing non-integrin; HIV gpl20-binding protein; MGC129965
Gene Symbols: CD209
Molecular weight: 45,775 Da
Basal Isoelectric point: 5.43  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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CD209

Protein Structure Not Found.
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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 S61 AGLLVQVSKVPSSIS
0 1 K62 GLLVQVSKVPSSISQ
0 1 S65 VQVSKVPSSISQEQS
0 1 S66 QVSKVPSSISQEQSR
0 1 Y101‑p KSKLQEIyQELTQLk
0 1 K108‑ac yQELTQLkAAVGELP
0 1 K131‑ac YQELTRLkAAVGELP
0 1 K154‑ac YQELTWLkAAVGELP
0 1 K177‑ac YQELTRLkAAVGELP
0 1 K200‑ac YQELTRLkAAVGELP
0 1 K223‑ac YQELTRLkAAVGELP
0 1 - gap
0 1 - gap
0 1 Y239‑p KSKQQEIyQELTQLK
0 1 S338‑p DGSPLLPsFKQYWNR
  CD209 iso7  
S17‑p QQLGLLVsKVPssIS
K18 QLGLLVsKVPssISQ
S21‑p LLVsKVPssISQEQS
S22‑p LVsKVPssISQEQSR
Y57 KSKLQEIYQELTQLK
K64 YQELTQLKAAVGELP
K87 YQELTRLKAAVGELP
K110 YQELTWLKAAVGELP
K133 YQELTRLKAAVGELP
K156 YQELTRLKAAVGELP
K179 YQELTRLKAAVGELP
- gap
- gap
Y195 KSKQQEIYQELTQLK
S294 DGSPLLPSFKQYWNR
  CD209 iso10  
S37 GYKSLAVSkVPSSIS
K38‑ub YKSLAVSkVPSSISQ
S41 LAVSkVPSSISQEQS
S42 AVSkVPSSISQEQSR
Y77 KSKLQEIYQELTQLK
K84 YQELTQLKAAVGELP
K107 YQELTRLKAAVGELP
K130 YQELTWLKAAVGELP
K153 YQELTRLKAAVGELP
K176 YQELTRLKAAVGELP
K199 YQELTRLKAAVGELP
- gap
- gap
Y215 KSKQQEIYQELTQLK
S314 DGSPLLPSFKQYWNR
  mouse

 
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
T21‑p PLDEELLtsSHTRHS
S22‑p LDEELLtsSHTRHSI
Y91 ENNQMNVYQELTQLK
S189 DGSPLTLSFMKYWSK
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