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Protein Page:
IKKG (human)
rdtyret
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
IKKG a regulatory subunit of the IKK-signalosome complex. Interacts preferentially with IKK-beta but also able to interact with IKK-alpha, IKAP, TAX, RIP and MAP3K14/NIK. Defects are the cause of familial incontinentia pigmenti type II (IP2). Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Protein kinase, regulatory subunit
Chromosomal Location of Human Ortholog: Xq28
Cellular Component: cytoplasm; cytosol; IkappaB kinase complex; intracellular; nucleus; spindle pole; ubiquitin ligase complex
Molecular Function: metal ion binding; peroxisome proliferator activated receptor binding; protein binding; protein domain specific binding; protein heterodimerization activity; protein homodimerization activity; signal transducer activity; ubiquitin protein ligase binding
Biological Process: activation of MAPK activity; activation of NF-kappaB transcription factor; activation of NF-kappaB-inducing kinase; apoptosis; B cell homeostasis; cell surface receptor linked signal transduction; establishment of vesicle localization; I-kappaB kinase/NF-kappaB cascade; immune response; inflammatory response; innate immune response; JNK cascade; MyD88-dependent toll-like receptor signaling pathway; MyD88-independent toll-like receptor signaling pathway; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of interferon type I production; positive regulation of transcription from RNA polymerase II promoter; response to DNA damage stimulus; response to virus; stimulatory C-type lectin receptor signaling pathway; stress-activated MAPK cascade; T cell receptor signaling pathway; toll-like receptor 10 signaling pathway; toll-like receptor 2 signaling pathway; toll-like receptor 3 signaling pathway; toll-like receptor 4 signaling pathway; toll-like receptor 5 signaling pathway; toll-like receptor 9 signaling pathway; toll-like receptor signaling pathway; transcription, DNA-dependent; tumor necrosis factor-mediated signaling pathway; viral reproduction
Disease: Ectodermal Dysplasia, Anhidrotic, With Immunodeficiency, Osteopetrosis, And Lymphedema; Ectodermal Dysplasia, Hypohidrotic, With Immune Deficiency; Immunodeficiency 33; Immunodeficiency Without Anhidrotic Ectodermal Dysplasia; Incontinentia Pigmenti; Invasive Pneumococcal Disease, Recurrent Isolated, 2
Reference #:  Q9Y6K9 (UniProtKB)
Alt. Names/Synonyms: AMCBX1; FIP-3; FIP3; Fip3p; I-kappa-B kinase subunit gamma; IkB kinase gamma subunit; IkB kinase subunit gamma; IkB kinase-associated protein 1; IKBKG; IKK-gamma; IKKAP1; IKKG; incontinentia pigmenti; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma; Inhibitor of nuclear factor kappa-B kinase subunit gamma; IP; IP1; IP2; IPD2; NEMO; NF-kappa-B essential modifier; NF-kappa-B essential modulator; NFkappaB essential modulator
Gene Symbols: IKBKG
Molecular weight: 48,198 Da
Basal Isoelectric point: 5.56  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  B Cell Receptor Signaling  |  Death Receptor Signaling  |  Inhibition of Apoptosis  |  Insulin Receptor Signaling  |  NF-kB Signaling  |  T Cell Receptor Signaling  |  Toll-Like Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

IKKG

Protein Structure Not Found.


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Sites Implicated In
transcription, altered: S85‑p
activity, induced: K285‑ub
enzymatic activity, inhibited: Y374‑p, S377‑p
intracellular localization: S85‑p
molecular association, regulation: S68‑p, S85‑p

Modification Sites and Domains  
Click here to view other types of protein modifications

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
1 3 S31‑p QDVLGEEsPLGKPAM
2 0 S43‑p PAMLHLPsEQGAPET
1 0 S68‑p LRDAIRQsNQILRER
4 0 S85‑p ELLHFQAsQREEKEF
0 1 K143‑ub AEDKASVkAQVTSLL
0 1 S178‑p EGRARAAsEQARQLE
0 1 S221 RMERQAASEEKRKLA
0 1 K255‑ac SVVGSERkRGMQLED
1 1 K277‑ub AEEALVAkQEVIDkL
5 0 K277‑sm AEEALVAkQEVIDkL
0 1 K283‑ub AkQEVIDkLkEEAEQ
5 14 K285‑ub QEVIDkLkEEAEQHk
0 1 K292‑ub kEEAEQHkIVMEtVP
0 1 T297‑p QHkIVMEtVPVLKAQ
0 1 Y308‑p LKAQADIykADFQAE
3 3 K309‑ub KAQADIykADFQAER
4 0 K309‑sm KAQADIykADFQAER
1 0 K321‑ub AERQAREkLAEkkEL
1 1 K325‑ub AREkLAEkkELLQEQ
1 0 K326‑ub REkLAEkkELLQEQL
0 15 K344‑ub QREYSKLkASCQESA
0 1 S350 LkASCQESARIEDMR
1 11 Y374‑p PLPPAPAyLssPLAL
3 7 S376‑p PPAPAyLssPLALPs
1 56 S377‑p PAPAyLssPLALPsQ
1 0 P382 LssPLALPsQRRsPP
0 5 S383‑p ssPLALPsQRRsPPE
1 18 S387‑p ALPsQRRsPPEEPPD
3 0 K399‑ub PPDFCCPkCQYQAPD
2689 : Phospho-IKKgamma (Ser376) Antibody
  IKKG iso2  
S99 QDVLGEESPLGKPAM
S111 PAMLHLPSEQGAPET
S136 LRDAIRQSNQILRER
S153 ELLHFQASQREEKEF
K211 AEDKASVKAQVTSLL
S246 EGRARAASEQARQLE
S289 RMERQAASEEKRKLA
K323 SVVGSERKRGMQLED
K345 AEEALVAKQEVIDKL
K345 AEEALVAKQEVIDKL
K351 AKQEVIDKLKEEAEQ
K353 QEVIDKLKEEAEQHK
K360 KEEAEQHKIVMETVP
T365 QHKIVMETVPVLKAQ
Y376 LKAQADIYKADFQAE
K377 KAQADIYKADFQAER
K377 KAQADIYKADFQAER
K389 AERQAREKLAEKKEL
K393 AREKLAEKKELLQEQ
K394 REKLAEKKELLQEQL
K412 QREYSKLKASCQESA
S418 LKASCQESARIEDMR
Y442 PLPPAPAYLSSPLAL
S444 PPAPAYLSSPLALPS
S445 PAPAYLSSPLALPSQ
P450 LSSPLALPSQRRSPP
S451 SSPLALPSQRRSPPE
S455 ALPSQRRSPPEEPPD
K467 PPDFCCPKCQYQAPD
  mouse

 
S31 QDMLGEESSLGKPAM
S43 PAMLHLPSEQGTPET
S68 LRDAIRQSNQMLRER
S85‑p ELLHFQVsQREEKEF
K143 AEDKASVKAQVTSLL
S178 EGRIRAVSEQVRQLE
S221‑p RMERQAAsEEKRKLA
- gap
K270‑ub AEEALVAkQELIDKL
K270‑sm AEEALVAkQELIDKL
K276 AkQELIDKLKEEAEQ
K278 QELIDKLKEEAEQHK
K285 KEEAEQHKIVMETVP
T290 QHKIVMETVPVLKAQ
Y301 LKAQADIYkADFQAE
K302‑ub KAQADIYkADFQAER
K302‑sm KAQADIYkADFQAER
K314 AERHAREKLVEKKEY
K318 AREKLVEKKEYLQEQ
K319 REKLVEKKEYLQEQL
K337‑ub QREFNKLkVGCHEsA
S343‑p LkVGCHEsARIEDMR
H367 PLLPAPAHHsFHLAL
S369‑p LPAPAHHsFHLALsN
F370 PAPAHHsFHLALsNQ
S375‑p HsFHLALsNQRRsPP
N376 sFHLALsNQRRsPPE
S380‑p ALsNQRRsPPEEPPD
K392 PPDFCCPKCQYQAPD
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