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Protein Page:
MAST2 (mouse)

MAST2 Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: AGC group; EC; Kinase, protein; MAST family; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)
Cellular Component: cytoplasm; microtubule cytoskeleton
Molecular Function: ATP binding; magnesium ion binding; microtubule binding; phosphatase binding; protein serine/threonine kinase activity
Biological Process: cytoskeleton organization and biogenesis; peptidyl-serine phosphorylation; protein amino acid phosphorylation; regulation of interleukin-12 biosynthetic process; spermatid differentiation
Reference #:  Q60592 (UniProtKB)
Alt. Names/Synonyms: Mast2; Mast205; microtubule associated serine/threonine kinase 2; microtubule associated testis specific serine/threonine protein kinase; Microtubule-associated serine/threonine-protein kinase 2; mKIAA0807; Mtssk
Gene Symbols: Mast2
Molecular weight: 190,534 Da
Basal Isoelectric point: 7.66  Predict pI for various phosphorylation states
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Protein Structure Not Found.
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