Transcription factor for the thyroid-specific expression of the genes exclusively expressed in the thyroid cell type, maintaining the functional differentiation of such cells. Interacts with WWTR1. Expressed in the excretory system, thyroid gland and Wilms tumors. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Molecular Function: DNA binding; protein binding; thyroid-stimulating hormone receptor activity; transcription factor activity
Biological Process: anatomical structure morphogenesis; central nervous system development; inner ear morphogenesis; kidney development; mesonephros development; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; pronephros development; regulation of apoptosis; sulfur metabolic process; thyroid gland development; transcription from RNA polymerase II promoter; transcription, DNA-dependent; ureteric bud branching; urogenital system development
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.