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Protein Page:
FOXP1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
FOXP1 Transcriptional repressor. It plays an important role in the specification and differentiation of lung epithelium. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Essential transcriptional regulator of B-cell development. Forms homodimers and heterodimers with FOXP2 and FOXP4. Dimerization is required for DNA-binding. Interacts with CTBP1. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; DNA-binding; C2H2-type zinc finger protein; Transcription factor
Chromosomal Location of Human Ortholog: 3p14.1
Cellular Component: nucleoplasm; nucleus
Molecular Function: androgen receptor binding; protein binding; protein self-association
Biological Process: endothelial cell activation; macrophage activation; monocyte activation; negative regulation of B cell apoptosis; negative regulation of transcription, DNA-dependent; osteoclast differentiation; positive regulation of smooth muscle cell proliferation; regulation of inflammatory response; regulation of interleukin-1 beta secretion; regulation of monocyte differentiation; regulation of tumor necrosis factor production; response to lipopolysaccharide
Disease: Mental Retardation With Language Impairment And With Or Without Autistic Features
Reference #:  Q9H334 (UniProtKB)
Alt. Names/Synonyms: 12CC4; FLJ23741; fork head-related protein like B; forkhead box P1; Forkhead box protein P1; FOXP1; glutamine-rich factor 1; hFKH1B; HSPC215; MGC12942; MGC88572; MGC99551; QRF1
Gene Symbols: FOXP1
Molecular weight: 75,317 Da
Basal Isoelectric point: 6.2  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

FOXP1

Protein Structure Not Found.
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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 S37 GGLREGRSNGETPAV
0 2 S79‑p QQQQQQVsGLKsPKR
0 12 S83‑p QQVsGLKsPKRNDKQ
0 1 N247 TAEETTGNNHSSLDL
0 1 T256 HSSLDLTTTCVSSSA
0 1 T257 SSLDLTTTCVSSSAP
0 2 T285‑p NGQLSVHtPKRESLS
0 1 T367‑p ERLQAMMtHLHVKST
0 1 K377‑ub HVKSTEPkAAPQPLN
0 1 T409 SLPHTPTTPTAPLTP
1 7 S440‑p GPIRRRYsDKYNVPI
0 1 K460 AQNQEFYKNAEVRPP
0 2 S615‑p GAMEHTNsNEsDssP
0 3 S618‑p EHTNsNEsDssPGRs
0 1 S620‑p TNsNEsDssPGRsPM
0 1 S621‑p NsNEsDssPGRsPMQ
0 9 S625‑p sDssPGRsPMQAVHP
0 1 S650 EEAEGPLSLVtTANH
0 1 T653‑p EGPLSLVtTANHsPD
0 4 S658‑p LVtTANHsPDFDHDR
  FOXP1 iso2  
- gap
- gap
- gap
N59 TAEETTGNNHSSLDL
T68 HSSLDLTTTCVSSSA
T69 SSLDLTTTCVSSSAP
T97 NGQLSVHTPKRESLS
T179 ERLQAMMTHLHVKST
K189 HVKSTEPKAAPQPLN
T221 SLPHTPTTPTAPLTP
S252 GPIRRRYSDKYNVPI
K272 AQNQEFYKNAEVRPP
S427 GAMEHTNSNESDSSP
S430 EHTNSNESDSSPGRS
S432 TNSNESDSSPGRSPM
S433 NSNESDSSPGRSPMQ
S437 SDSSPGRSPMQAVHP
S462 EEAEGPLSLVTTANH
T465 EGPLSLVTTANHSPD
S470 LVTTANHSPDFDHDR
  mouse

 
S37‑p GALRDTRsNGEAPAV
S109 QQQQQQVSGLKsPKR
S113‑p QQVSGLKsPKRNDKQ
S275 TAEETTSSNHSSLDL
S284 HSSLDLTSTCVSSSA
T285 SSLDLTSTCVSSSAP
T313 NGQLSVHTPKRESLS
T395 ERLQAMMTHLHVKST
K405 HVKSTEPKAAPQPLN
T437‑p SLPHTPTtPTAPLTP
S468‑p GPIRRRYsDKYNVPI
K488‑ac AQNQEFYkNAEVRPP
S643 GAMEHTNSNESDSSP
S646 EHTNSNESDSSPGRS
S648 TNSNESDSSPGRSPM
S649 NSNESDSSPGRSPMQ
S653 SDSSPGRSPMQAVHP
S678‑p EEAEGPLsLVTTANH
T681 EGPLsLVTTANHsPD
S686‑p LVTTANHsPDFDHDR
  rat

 
S37 GTLRDTRSNGEAPAV
S111 QQQQQQVSGLKSPKR
S115 QQVSGLKSPKRNDKQ
S281‑p TAEETTGsNHSSLDL
S290‑p HSSLDLTstCVSSSA
T291‑p SSLDLTstCVSSSAP
T319 NGQLSVHTPKRESLS
T401 ERLQAMMTHLHVKST
K411 HVKSTEPKAAPQPLN
T443 SLPHTPTTPTAPLTP
S474 GPIRRRYSDKYNVPI
K494 AQNQEFYKNAEVRPP
S649 GAMEHTNSNESDSSP
S652 EHTNSNESDSSPGRS
S654 TNSNESDSSPGRSPM
S655 NSNESDSSPGRSPMQ
S659 SDSSPGRSPMQAVHP
S684 EEAEGPLSLVTTANH
T687 EGPLSLVTTANHSPD
S692 LVTTANHSPDFDHDR
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