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Protein Page:
FOXP1 (human)

Overview
FOXP1 Transcriptional repressor. It plays an important role in the specification and differentiation of lung epithelium. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Essential transcriptional regulator of B-cell development. Forms homodimers and heterodimers with FOXP2 and FOXP4. Dimerization is required for DNA-binding. Interacts with CTBP1. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: C2H2-type zinc finger protein; Cell cycle regulation; DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 3p14.1
Cellular Component: nucleoplasm; nucleus
Molecular Function: androgen receptor binding; protein binding; protein self-association
Biological Process: endothelial cell activation; macrophage activation; monocyte activation; negative regulation of B cell apoptosis; negative regulation of transcription, DNA-dependent; osteoclast differentiation; positive regulation of smooth muscle cell proliferation; regulation of inflammatory response; regulation of interleukin-1 beta secretion; regulation of monocyte differentiation; regulation of tumor necrosis factor production; response to lipopolysaccharide
Disease: Mental Retardation With Language Impairment And With Or Without Autistic Features
Reference #:  Q9H334 (UniProtKB)
Alt. Names/Synonyms: 12CC4; FLJ23741; fork head-related protein like B; forkhead box P1; Forkhead box protein P1; FOXP1; glutamine-rich factor 1; hFKH1B; HSPC215; MGC12942; MGC88572; MGC99551; QRF1
Gene Symbols: FOXP1
Molecular weight: 75,317 Da
Basal Isoelectric point: 6.2  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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FOXP1

Protein Structure Not Found.
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