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Protein Page:
AP-2 gamma (human)

Overview
AP-2 gamma Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. Binds DNA as a dimer. Can form homodimers or heterodimers with other AP-2 family members. Interacts with WWOX. Interacts with CITED4. Interacts with UBE2I. Interacts with KCTD1; this interaction represses transcription activation. Interacts with CITED2 (via C-terminus); the interaction stimulates TFAP2B-transcriptional activity. During retinoic acid-mediated differentiation. Belongs to the AP-2 family. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Motility/polarity/chemotaxis; Transcription factor
Chromosomal Location of Human Ortholog: 20q13.2
Cellular Component: mitochondrion; nucleoplasm; nucleus
Molecular Function: DNA binding; protein binding; protein dimerization activity; transcription factor activity
Biological Process: cell-cell signaling; male gonad development; positive regulation of transcription from RNA polymerase II promoter; regulation of cell proliferation; regulation of gene expression, epigenetic; regulation of transcription from RNA polymerase II promoter
Reference #:  Q92754 (UniProtKB)
Alt. Names/Synonyms: Activating enhancer-binding protein 2 gamma; AP2-gamma; AP2C; ERF1; estrogen receptor factor 1; hAP-2g; TFAP2C; TFAP2G; Transcription factor AP-2 gamma; transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma); transcription factor AP-2 gamma (activating enhancer-binding protein 2 gamma); Transcription factor ERF-1
Gene Symbols: TFAP2C
Molecular weight: 49,177 Da
Basal Isoelectric point: 7.72  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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AP-2 gamma

Protein Structure Not Found.


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