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Protein Page:
TCF7 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
TCF7 Transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4(+) CD8(+) immature thymocytes. Isoforms lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. Binds to the T- lymphocyte-specific enhancer element (5'-WWCAAAG-3') found in the promoter of the CD3E gene. May also act as feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7 and CTNNB1. Binds the armadillo repeat of CTNNB1 and forms a stable complex. Interacts with AES, TLE1, TLE2, TLE3 and TLE4. By TCF7L2 and CTNNB1. Predominantly expressed in T-cells. Also detected in proliferating intestinal epithelial cells and in the basal epithelial cells of mammary gland epithelium. Belongs to the TCF/LEF family. 16 isoforms of the human protein are produced by alternative promoter. Note: This description may include information from UniProtKB.
Protein type: Transcription factor; DNA-binding
Chromosomal Location of Human Ortholog: 5q31.1
Cellular Component: nucleoplasm; nucleus; transcription factor complex
Molecular Function: beta-catenin binding; protein binding; sequence-specific DNA binding
Biological Process: immune response; regulation of transcription from RNA polymerase II promoter; Wnt receptor signaling pathway through beta-catenin
Reference #:  P36402 (UniProtKB)
Alt. Names/Synonyms: FLJ36364; MGC47735; T-cell factor 1; T-cell-specific transcription factor 1; TCF-1; TCF-7; TCF1; TCF7; Transcription factor 7; transcription factor 7 (T-cell specific, HMG-box); transcription factor-7, T-cell specific
Gene Symbols: TCF7
Molecular weight: 41,642 Da
Basal Isoelectric point: 6.32  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics  |  Wnt/ß-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TCF7

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 S37‑p GEEQDDKsRDSAAGP
0 1 K52‑ub ERDLAELkSSLVNES
0 1 K98‑ub AQRLFPDkLPEPLED
0 2 K108‑ub EPLEDGLkAPECTSG
0 1 Y117‑p PECTSGMyKETVYSA
0 6 S161‑p PHGVPQLsLyEHFNs
0 39 Y163‑p GVPQLsLyEHFNsPH
0 4 S168‑p sLyEHFNsPHPtPAP
0 1 T172‑p HFNsPHPtPAPADIs
0 1 S179‑p tPAPADIsQkQVHRP
0 1 K181‑ub APADIsQkQVHRPLQ
0 9 K253‑ub QPFDRNLkTQAESkA
0 3 K259‑ub LkTQAESkAEKEAKK
0 1 K271‑ub AKKPTIKkPLNAFML
0 2 K286‑ub YMKEMRAkVIAECTL
0 2 K294‑ub VIAECTLkESAAINQ
0 9 K317‑ub LSREEQAkYYELARK
0 12 Y333‑p RQLHMQLyPGWSARD
0 1 K352 KKRRSREKHQESTTE
0 1 - gap
  TCF7 iso4  
- gap
- gap
- gap
- gap
Y2 ______MYKETVYSA
S46 PHGVPQLSLYEHFNS
Y48 GVPQLSLYEHFNSPH
S53 SLYEHFNSPHPTPAP
T57 HFNSPHPTPAPADIS
S64 TPAPADISQKQVHRP
K66 APADISQKQVHRPLQ
K138 QPFDRNLKTQAESKA
K144 LKTQAESKAEKEAKK
K156 AKKPTIKKPLNAFML
K171 YMKEMRAKVIAECTL
K179 VIAECTLKESAAINQ
K202 LSREEQAKYYELARK
Y218 RQLHMQLYPGWSARD
K237 KKRRSREKHQESTTD
- gap
  TCF7 iso5  
S37 GEEQDDKSRDSAAGP
K52 ERDLAELKSSLVNES
K98 AQRLFPDKLPEPLED
K108 EPLEDGLKAPECTSG
Y117 PECTSGMYKETVYSA
S161 PHGVPQLSLYEHFNS
Y163 GVPQLSLYEHFNSPH
S168 SLYEHFNSPHPTPAP
T172 HFNSPHPTPAPADIS
S179 TPAPADISQKQVHRP
K181 APADISQKQVHRPLQ
K253 QPFDRNLKTQAESKA
K259 LKTQAESKAEKEAKK
K271 AKKPTIKKPLNAFML
K286 YMKEMRAKVIAECTL
K294 VIAECTLKESAAINQ
K317 LSREEQAKYYELARK
Y333 RQLHMQLYPGWSARD
K352 KKRRSREKHQESTTG
- gap
  TCF7 iso6  
- gap
- gap
- gap
- gap
Y2 ______MYKETVYSA
S46 PHGVPQLSLYEHFNS
Y48 GVPQLSLYEHFNSPH
S53 SLYEHFNSPHPTPAP
T57 HFNSPHPTPAPADIS
S64 TPAPADISQKQVHRP
K66 APADISQKQVHRPLQ
K138 QPFDRNLKTQAESKA
K144 LKTQAESKAEKEAKK
K156 AKKPTIKKPLNAFML
K171 YMKEMRAKVIAECTL
K179 VIAECTLKESAAINQ
K202 LSREEQAKYYELARK
Y218 RQLHMQLYPGWSARD
K237 KKRRSREKHQESTTG
- gap
  TCF7 iso10  
- gap
- gap
- gap
- gap
Y2 ______MYKETVYSA
S46 PHGVPQLSLYEHFNS
Y48 GVPQLSLYEHFNSPH
S53 SLYEHFNSPHPTPAP
T57 HFNSPHPTPAPADIS
S64 TPAPADISQKQVHRP
K66 APADISQKQVHRPLQ
K138‑ub QPFDRNLkTQAESKA
K144 LkTQAESKAEKEAKK
K156 AKKPTIKKPLNAFML
K171 YMKEMRAKVIAECTL
K179 VIAECTLKESAAINQ
K202 LSREEQAKYYELARK
Y218 RQLHMQLYPGWSARD
K237‑ub KKRRSREkHQESTTD
S250‑p TDNSLHYs_______
  mouse

 
N37 GEEQDDKNRDSPVGP
K52 ERDLAELKSSLVNES
K99 SQRLFPDKLPESLED
K109 ESLEDGLKAPECTSG
Y118 PECTSGMYKETVYSA
S163 PHGVPQLSPLYEHFS
Y166 VPQLSPLYEHFSSPH
S171 PLYEHFSSPHPTPAP
T175 HFSSPHPTPAPADIS
S182 TPAPADISQKQGVHR
K184 APADISQKQGVHRPL
K288 QPYDRNLKTQAEPKA
K294 LKTQAEPKAEKEAKK
K306 AKKPVIKKPLNAFML
K321 YMKEMRAKVIAECTL
K329 VIAECTLKESAAINQ
K352 LSREEQAKYYELARK
Y368 RQLHMQLYPGWSARD
K387 KKRRSREKHQESTTG
- gap
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