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Protein Page:
TECPR1 (human)

Overview
TECPR1 Tethering factor involved in autophagy. Involved in autophagosome maturation by promoting the autophagosome fusion with lysosomes: acts by associating with both the ATG5-ATG12 conjugate and phosphatidylinositol-3-phosphate (PtdIns(3)P) present at the surface of autophagosomes. Also involved in selective autophagy against bacterial pathogens, by being required for phagophore/preautophagosomal structure biogenesis and maturation. Interacts with ATG5; the interaction is direct. Interacts with WIPI2. Interacts with the ATG5-ATG12 conjugate, the interaction is however mutually exclusive with ATG16, since it does not interact with ATG12-ATG5-ATG16 complex. Belongs to the TECPR1 family. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Autophagy; Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 7q21.3
Cellular Component: lysosomal membrane
Molecular Function: phosphatidylinositol 3-phosphate binding; protein binding
Biological Process: autophagy
Reference #:  Q7Z6L1 (UniProtKB)
Alt. Names/Synonyms: DKFZP434B0335; FLJ23419; FLJ90593; KIAA1358; TCPR1; TECPR1; tectonin beta-propeller repeat containing 1; Tectonin beta-propeller repeat-containing protein 1
Gene Symbols: TECPR1
Molecular weight: 129,696 Da
Basal Isoelectric point: 5.83  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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TECPR1

Protein Structure Not Found.
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