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Protein Page:
SEC24D (human)

SEC24D Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex. COPII is composed of at least five proteins: the Sec23/24 complex, the Sec13/31 complex and Sar1. Interacts with TMED2 and TMED10. Ubiquitously expressed, with higher amounts in placenta, pancreas, heart and liver. Belongs to the SEC23/SEC24 family. SEC24 subfamily. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Chromosomal Location of Human Ortholog: 4q26
Cellular Component: cytosol; endoplasmic reticulum membrane
Molecular Function: protein binding
Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class II; antigen processing and presentation of peptide antigen via MHC class I; COPII coating of Golgi vesicle; ER to Golgi vesicle-mediated transport
Disease: Cole-carpenter Syndrome 2
Reference #:  O94855 (UniProtKB)
Alt. Names/Synonyms: FLJ43974; KIAA0755; Protein transport protein Sec24D; SC24D; SEC24 family, member D (S. cerevisiae); SEC24 related gene family, member D; SEC24-related protein D; SEC24D
Gene Symbols: SEC24D
Molecular weight: 113,010 Da
Basal Isoelectric point: 6.91  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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