Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Protein Page:
SEC24D (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
SEC24D Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex. COPII is composed of at least five proteins: the Sec23/24 complex, the Sec13/31 complex and Sar1. Interacts with TMED2 and TMED10. Ubiquitously expressed, with higher amounts in placenta, pancreas, heart and liver. Belongs to the SEC23/SEC24 family. SEC24 subfamily. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Chromosomal Location of Human Ortholog: 4q26
Cellular Component: COPII vesicle coat; cytosol; endoplasmic reticulum membrane; Golgi membrane; perinuclear region of cytoplasm
Molecular Function: protein binding; zinc ion binding
Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class II; antigen processing and presentation of peptide antigen via MHC class I; COPII coating of Golgi vesicle; ER to Golgi vesicle-mediated transport; in utero embryonic development; intracellular protein transport
Disease: Cole-carpenter Syndrome 2
Reference #:  O94855 (UniProtKB)
Gene Symbols: SEC24D
Molecular weight: 113,010 Da
Basal Isoelectric point: 6.91  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SEC24D

Protein Structure Not Found.


STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K258 GPPQPQKKLDPDSIP
0 7 S266‑p LDPDSIPsPIQVIEN
0 2 Y283‑p ASRGGQVyATNTRGQ
0 1 K594‑ub AEAPGKLkNRDDKKL
0 1 K608 LVNTDKEKILFQPQT
0 1 S779‑p QLADLYKsCETDALI
0 4 K791‑ub ALINFFAkSAFkAVL
0 2 K795‑ub FFAkSAFkAVLHQPL
0 1 K803 AVLHQPLKVIREILV
0 1 T813 REILVNQTAHMLACY
0 4 S826‑p CYRKNCAsPSAAsQL
0 1 S831‑p CAsPSAAsQLILPDS
0 1 K840 LILPDSMKVLPVYMN
0 1 S899‑p IHTLDVKsTMLPAAV
0 1 S911‑p AAVRCSEsRLSEEGI
0 1 T988‑p RPYSMKLtIVKQREQ
  mouse

 
K258‑ub PAPQLQRkLDPDSIP
S266‑p LDPDSIPsPIQVIEN
Y283 ATRGGQVYTTNTRGQ
K594 AEAPGKLKNRDDKKL
K608‑ub LVNTDKEkILFQPQT
S779 QLADLYKSCETDALI
K791 ALINFFAKSAFkAVL
K795‑ub FFAKSAFkAVLNQPL
K803‑ub AVLNQPLkAIREILV
T813 REILVNQTAHMLACY
S826‑p CYRKHCAsPSAASQL
S831 CAsPSAASQLILPDS
K840‑ub LILPDSMkVLPVYMN
S899 IHTLDVKSAALPPAV
S911 PAVRCSESRLSEEGI
I988 KPYSMKLIVVKQREQ
  rat

 
- gap
- gap
- gap
K131 AEAPGKLKNRDDKKL
K145 LVNTDKEKILFQPQT
S316 QLADLYKSCETDALI
K328 ALINFFAKSAFKAVL
K332 FFAKSAFKAVLNQPL
K340 AVLNQPLKTIREILV
T350‑p REILVNQtAHMLACY
S363 CYRKHCASPSAASQL
S368 CASPSAASQLILPDS
K377 LILPDSMKVLPVYMN
S436 IHTLDVKSAALPPAV
S448 PAVRCSESRLSEEGI
I525 KPYSMKLIIVKQREQ
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.