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Protein Page:
TIF1G (human)

Overview
TIF1G an atypical protein kinase that functions as a transcriptional repressor. Translocation with RET generates the TRIM33/RET (PTC7) oncogene. The protein is a member of the tripartite motif family. This motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. Two splice variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: ATYPICAL group; EC 6.3.2.-; EC 6.3.2.19; Kinase, protein; Ligase; Protein kinase, atypical; TIF1 family; Transcription, coactivator/corepressor; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of Human Ortholog: 1p13.1
Cellular Component: intracellular membrane-bound organelle; nucleoplasm; nucleus
Molecular Function: protein binding; ubiquitin-protein ligase activity
Biological Process: negative regulation of BMP signaling pathway; negative regulation of transcription from RNA polymerase II promoter; protein ubiquitination; regulation of transforming growth factor beta receptor signaling pathway
Disease: Thyroid Carcinoma, Papillary
Reference #:  Q9UPN9 (UniProtKB)
Alt. Names/Synonyms: E3 ubiquitin-protein ligase TRIM33; Ectodermin homolog; FLJ32925; KIAA1113; Protein Rfg7; PTC7; RET-fused gene 7 protein; RFG7; TF1G; TIF1-gamma; TIF1G; TIF1GAMMA; TIFGAMMA; Transcription intermediary factor 1-gamma; transcriptional intermediary factor 1 gamma; TRI33; TRIM33; tripartite motif-containing 33; Tripartite motif-containing protein 33
Gene Symbols: TRIM33
Molecular weight: 122,533 Da
Basal Isoelectric point: 6.23  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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TIF1G

Protein Structure Not Found.
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