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Protein Page:
TIF1B (human)

TIF1B an atypical protein kinase that functions as a transcriptional coactivator. Mediates transcriptional regulation by interaction with the Kruppel-associated box (KRAB) repression domain found in many transcription factors. Binds to the negative regulatory domain of c-Myb and negatively regulates the c-Myb-dependent trans-activation. Localizes to the nucleus and is thought to associate with specific chromatin regions. Phosphorylated in an ATM-dependent manner following double-strand breaks. Its phosphorylation in response to DNA damage leads to chromatin relaxation. A member of the tripartite motif family. The tripartite motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. Note: This description may include information from UniProtKB.
Protein type: ATYPICAL group; EC 6.3.2.-; Kinase, protein; Ligase; Nuclear receptor co-regulator; Protein kinase, atypical; TIF1 family; Transcription, coactivator/corepressor; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of Human Ortholog: 19q13.43
Cellular Component: nucleoplasm; nucleus
Molecular Function: chromatin binding; DNA binding; protein binding; sequence-specific DNA binding; transcription corepressor activity; transcription factor activity; ubiquitin protein ligase binding; ubiquitin-protein ligase activity; zinc ion binding
Biological Process: DNA repair; epithelial to mesenchymal transition; innate immune response; negative regulation of transcription, DNA-dependent; positive regulation of DNA repair; positive regulation of transcription factor import into nucleus; positive regulation of transcription, DNA-dependent; protein oligomerization; protein sumoylation; Ras protein signal transduction; transcription initiation from RNA polymerase II promoter
Reference #:  Q13263 (UniProtKB)
Alt. Names/Synonyms: FLJ29029; KAP-1; KAP1; KRAB-associated protein 1; KRAB-interacting protein 1; KRIP-1; Nuclear corepressor KAP-1; RING finger protein 96; RNF96; TF1B; TIF1-beta; TIF1B; Transcription intermediary factor 1-beta; transcriptional intermediary factor 1-beta; TRIM28; tripartite motif-containing 28; Tripartite motif-containing protein 28
Gene Symbols: TRIM28
Molecular weight: 88,550 Da
Basal Isoelectric point: 5.52  Predict pI for various phosphorylation states
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