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Protein Page:
PDGFB (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PDGFB Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFA. A chromosomal aberration involving PDGFB is found in dermatofibrosarcoma protuberans. Translocation t(17;22)(q22;q13) with PDGFB. Belongs to the PDGF/VEGF growth factor family. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Secreted, signal peptide; Secreted; Oncoprotein
Chromosomal Location of Human Ortholog: 22q13.1
Cellular Component: basolateral plasma membrane; cell surface; cytoplasm; endoplasmic reticulum lumen; extracellular region; extracellular space; Golgi membrane
Molecular Function: chemoattractant activity; collagen binding; growth factor activity; identical protein binding; platelet-derived growth factor binding; platelet-derived growth factor receptor binding; protein binding; protein heterodimerization activity; protein homodimerization activity; superoxide-generating NADPH oxidase activator activity
Biological Process: activation of MAPKK activity; activation of protein kinase activity; activation of protein kinase B; axon guidance; blood coagulation; cell growth; DNA replication; embryonic placenta development; epidermal growth factor receptor signaling pathway; extracellular matrix organization and biogenesis; fibroblast growth factor receptor signaling pathway; heart development; hemopoiesis; innate immune response; insulin receptor signaling pathway; MAPKKK cascade; monocyte chemotaxis; negative regulation of phosphatidylinositol biosynthetic process; negative regulation of protein binding; negative regulation of transcription, DNA-dependent; nerve growth factor receptor signaling pathway; peptidyl-serine phosphorylation; peptidyl-tyrosine phosphorylation; phosphoinositide-mediated signaling; platelet activation; platelet degranulation; platelet-derived growth factor receptor signaling pathway; positive chemotaxis; positive regulation of blood vessel endothelial cell migration; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of chemotaxis; positive regulation of cyclin-dependent protein kinase activity; positive regulation of DNA replication; positive regulation of endothelial cell proliferation; positive regulation of fibroblast proliferation; positive regulation of glomerular filtration; positive regulation of MAP kinase activity; positive regulation of MAPKKK cascade; positive regulation of mitosis; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of phosphoinositide 3-kinase activity; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of protein amino acid autophosphorylation; positive regulation of smooth muscle cell migration; positive regulation of smooth muscle cell proliferation; positive regulation of transcription, DNA-dependent; protein amino acid phosphorylation; Ras protein signal transduction; response to drug; response to estradiol stimulus; response to hypoxia; response to wounding; small GTPase mediated signal transduction; transforming growth factor beta receptor signaling pathway; vascular endothelial growth factor receptor signaling pathway
Disease: Basal Ganglia Calcification, Idiopathic, 1; Basal Ganglia Calcification, Idiopathic, 5; Dermatofibrosarcoma Protuberans; Meningioma, Familial, Susceptibility To
Reference #:  P01127 (UniProtKB)
Alt. Names/Synonyms: becaplermin; c-sis; FLJ12858; PDGF subunit B; PDGF, B chain; PDGF-2; PDGF2; PDGFB; platelet-derived growth factor 2; Platelet-derived growth factor B chain; Platelet-derived growth factor beta polypeptide; platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog); Platelet-derived growth factor subunit B; platelet-derived growth factor, B chain; Platelet-derived growth factor, beta polypeptide (oncogene SIS); Proto-oncogene c-Sis; SIS; SSV
Gene Symbols: PDGFB
Molecular weight: 27,283 Da
Basal Isoelectric point: 9.39  Predict pI for various phosphorylation states
CST Pathways:  Angiogenesis
Select Structure to View Below

PDGFB

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S82 SLARGRRSLGSLTIA
0 1 S85 RGRRSLGSLTIAEPA
0 1 A185 CKCETVAAARPVtRS
0 1 T190 VAAARPVTRSPGGsQ
0 1 T190‑ga VAAARPVtRSPGGsQ
0 1 S192 AARPVtRSPGGsQEQ
0 1 S196‑p VtRSPGGsQEQRAKT
  mouse

 
S82‑p SSSRGRRsLGsLAAA
S85‑p RGRRsLGsLAAAEPA
T185‑p CKCETIVtPRPVtRs
T190‑p IVtPRPVtRsPGTSR
T190 IVtPRPVTRsPGTSR
S192‑p tPRPVtRsPGTSREQ
S196 VtRsPGTSREQRAKT
  rat

 
S74 SSSRGRRSLGSLAAA
S77 RGRRSLGSLAAAEPA
T177 CKCETVVTPRPVTRS
T182 VVTPRPVTRSPGTSR
T182 VVTPRPVTRSPGTSR
S184 TPRPVTRSPGTSREH
S188 VTRSPGTSREHRAKT
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