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Protein Page:
ACTA2 (human)

Overview
ACTA2 Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others. Up-regulated in response to enterovirus 71 (EV71) infection. Belongs to the actin family. Note: This description may include information from UniProtKB.
Protein type: Contractile; Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 10q23.3
Cellular Component: cytoplasm; cytosol; extracellular space; filopodium; lamellipodium; protein complex
Molecular Function: protein kinase binding
Biological Process: muscle contraction; response to virus
Disease: Aortic Aneurysm, Familial Thoracic 6; Moyamoya Disease 5; Multisystemic Smooth Muscle Dysfunction Syndrome
Reference #:  P62736 (UniProtKB)
Alt. Names/Synonyms: AAT6; ACTA; ACTA2; actin, alpha 2, smooth muscle, aorta; Actin, aortic smooth muscle; ACTSA; ACTVS; alpha 2 actin; Alpha-actin-2; alpha-cardiac actin; Cell growth-inhibiting gene 46 protein; growth-inhibiting gene 46
Gene Symbols: ACTA2
Molecular weight: 42,009 Da
Basal Isoelectric point: 5.24  Predict pI for various phosphorylation states
CST Pathways:  Death Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ACTA2

Protein Structure Not Found.


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