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Protein Page:
PIK3R5 (human)

Overview
PIK3R5 Regulatory subunit of the PI3K gamma complex. Heterodimer of a catalytic subunit (PIK3CG/p120) and a regulatory (PIK3R5a/p101) subunit. Interacts with G beta gamma proteins. Ubiquitously expressed with high expression in fetal brain compared to adult brain. Abundant expression is observed in cerebellum, cerebral cortex, cerebral meninges, and vermis cerebelli. Greatly activated by G gamma proteins. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 17p13.1
Cellular Component: cytoplasm; cytosol; membrane
Molecular Function: G-protein beta/gamma-subunit binding; phosphatidylinositol-4,5-bisphosphate 3-kinase activity
Biological Process: G-protein coupled receptor protein signaling pathway; phosphatidylinositol biosynthetic process; phosphoinositide 3-kinase cascade; platelet activation; positive regulation of MAP kinase activity; positive regulation of protein kinase B signaling cascade
Disease: Ataxia-oculomotor Apraxia 3
Reference #:  Q8WYR1 (UniProtKB)
Alt. Names/Synonyms: F730038I15Rik; FOAP-2; p101; p101-PI3K; Phosphatidylinositol-4,5-bisphosphate 3-kinase regulatory subunit; Phosphoinositide 3-kinase regulatory subunit 5; phosphoinositide-3-kinase, regulatory subunit 5; phosphoinositide-3-kinase, regulatory subunit 5, p101; phosphoinositide-3-kinase, regulatory subunit, polypeptide p101; PI3-kinase p101 subunit; PI3-kinase regulatory subunit 5; PI3R5; PIK3R5; Protein FOAP-2; PtdIns-3-kinase p101; PtdIns-3-kinase regulatory subunit
Gene Symbols: PIK3R5
Molecular weight: 97,348 Da
Basal Isoelectric point: 6.3  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Adherens Junction Dynamics  |  AMPK Signaling  |  Angiogenesis  |  Apoptosis Regulation  |  ErbB/HER Signaling  |  ESC Pluripotency and Differentiation  |  Growth And Differentiation Control by MAPKs  |  IL6 Signaling  |  Inhibition of Apoptosis  |  Microtubule Dynamics  |  Mitochondrial Control of Apoptosis  |  mTOR Signaling  |  NF-kB Signaling  |  PI3K/Akt Signaling  |  Protein Kinase C Signaling  |  SAPK/JNK Signaling Cascades  |  T Cell Receptor Signaling  |  TGF-ß Signaling  |  Translation: eIF4E and p70S6K  |  Warburg Effect
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PIK3R5

Protein Structure Not Found.


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