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Protein Page:
FGF9 (human)

Overview
FGF9 Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors. Defects in FGF9 are the cause of multiple synostoses syndrome type 3 (SYNS3). Multiple synostoses syndrome is an autosomal dominant condition characterized by progressive joint fusions of the fingers, wrists, ankles and cervical spine, characteristic facies and progressive conductive deafness. Belongs to the heparin-binding growth factors family. Note: This description may include information from UniProtKB.
Protein type: Cytokine
Chromosomal Location of Human Ortholog: 13q11-q12
Cellular Component: extracellular region; extracellular space
Molecular Function: 1-phosphatidylinositol-3-kinase activity; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; protein-tyrosine kinase activity; Ras guanyl-nucleotide exchange factor activity
Biological Process: fibroblast growth factor receptor signaling pathway; male gonad development; MAPKKK cascade; phosphoinositide-mediated signaling; positive regulation of cell proliferation; regulation of phosphoinositide 3-kinase cascade; signal transduction; substantia nigra development
Disease: Multiple Synostoses Syndrome 3
Reference #:  P31371 (UniProtKB)
Alt. Names/Synonyms: FGF-9; FGF9; Fibroblast growth factor 9; fibroblast growth factor 9 (glia-activating factor); GAF; Glia-activating factor; HBFG-9; HBGF-9; Heparin-binding growth factor 9; MGC119914; MGC119915; SYNS3
Gene Symbols: FGF9
Molecular weight: 23,441 Da
Basal Isoelectric point: 7.06  Predict pI for various phosphorylation states
Select Structure to View Below

FGF9

Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 Y163‑p VDTGRRYyVALNKDG
0 1 T176‑p DGTPREGtRtKRHQK
0 1 T178‑p TPREGtRtKRHQKFT
  mouse

 
Y163 VDTGRRYYVALNKDG
T176 DGTPREGTRTKRHQK
T178 TPREGTRTKRHQKFT
  rat

 
Y163 VDTGRRYYVALNKDG
T176 DGTPREGTRTKRHQK
T178 TPREGTRTKRHQKFT
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