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Protein Page:
CD8A (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CD8A Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains. In general heterodimer of an alpha and a beta chain linked by two disulfide bonds. Can also form homodimers. Shown to be expressed as heterodimer on thymocytes and as homodimer on peripheral blood T-lymphocytes. Interacts with the MHC class I HLA-A/B2M dimer. Interacts with LCK in a zinc-dependent manner. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 2p12
Cellular Component: external side of plasma membrane; extracellular region; integral to plasma membrane; plasma membrane; T cell receptor complex
Molecular Function: coreceptor activity; MHC class I protein binding; protein binding; protein homodimerization activity; protein kinase binding
Biological Process: antigen processing and presentation; cell surface receptor linked signal transduction; cytotoxic T cell differentiation; defense response to virus; immune response; positive regulation of calcium-mediated signaling; regulation of immune response; T cell activation; T cell mediated immunity; transmembrane receptor protein tyrosine kinase signaling pathway
Disease: Cd8 Deficiency, Familial
Reference #:  P01732 (UniProtKB)
Gene Symbols: CD8A
Molecular weight: 25,729 Da
Basal Isoelectric point: 9.64  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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CD8A

Protein Structure Not Found.
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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 S158 TIASQPLSLRPEACR
0 1 S224‑p CPRPVVKsGDKPsLs
1 0 K227 PVVKsGDKPsLsARY
0 1 S229‑p VKsGDKPsLsARYV_
0 1 S231‑p sGDKPsLsARYV___
  CD8A iso2  
S158‑p TIASQPLsLRPEACR
S187 CPRPVVKSGDkPSLS
K190‑ub PVVKSGDkPSLSARY
S192 VKSGDkPSLSARYV_
S194 SGDkPSLSARYV___
  mouse

 
P172 HPTGTSQPQRPEDCR
- gap
K239 PLVRQEGKPRPSEKI
R241 VRQEGKPRPSEKIV_
S243 QEGKPRPSEKIV___
  rat

 
P163 PPTGTPRPLRPEACR
- gap
K228 KCPRPLVKPRPSEKF
R230 PRPLVKPRPSEKFV_
S232 PLVKPRPSEKFV___
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