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Protein Page:
CARD9 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CARD9 Activates NF-kappa-B via BCL10. Defects in CARD9 are the cause of familial candidiasis type 2 (CANDF2). Chronic mucocutaneous candidiasis is characterized by impaired clearance of fungal infections and results in colonization and infections of the mucosa or skin, predominantly with Candida albicans. CANDF2 is an autosomal recessive chronic mucocutaneous candidiasis. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 9q34.3
Cellular Component: cytoplasm; cytosol; plasma membrane
Molecular Function: CARD domain binding; protein binding; protein homodimerization activity
Biological Process: defense response to Gram-positive bacterium; defense response to virus; I-kappaB kinase/NF-kappaB cascade; innate immune response; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of interleukin-6 production; positive regulation of JNK cascade; positive regulation of stress-activated MAPK cascade; positive regulation of tumor necrosis factor production; regulation of apoptosis; regulation of interleukin-2 biosynthetic process; regulation of interleukin-6 biosynthetic process; regulation of tumor necrosis factor biosynthetic process; response to drug; response to exogenous dsRNA; response to fungus; response to muramyl dipeptide; response to peptidoglycan; stimulatory C-type lectin receptor signaling pathway
Disease: Candidiasis, Familial, 2
Reference #:  Q9H257 (UniProtKB)
Alt. Names/Synonyms: CARD9; caspase recruitment domain family, member 9; Caspase recruitment domain-containing protein 9; hCARD9
Gene Symbols: CARD9
Molecular weight: 62,241 Da
Basal Isoelectric point: 5.79  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CARD9

Protein Structure Not Found.


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Sites Implicated In
activity, inhibited: T531‑p, T533‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 S2 ______MSDYENDDE
0 1 Y76‑p QRTGHKGyVAFLESL
0 1 S82 GyVAFLESLELyYPQ
0 1 Y86‑p FLESLELyYPQLYKK
0 1 Y87 LESLELyYPQLYKKV
0 1 Y91 ELyYPQLYKKVtGKE
1 1 T95‑p PQLYKKVtGKEPARV
1 0 K125‑ub LLMTEVMkLQKKVQD
0 1 S152‑p KELRVKDsLLRKHQE
1 0 T231‑p CKVERKHtLKLRHAM
0 1 S276‑p QEGKLDRssPYIQVL
0 1 S277‑p EGKLDRssPYIQVLE
0 1 Y339‑p LRKDSKMyKDRIEAI
0 1 A354 LLQMEEVAIERDQAI
0 2 S424 QLETLVLSsDLEDGs
0 6 S425‑p LETLVLSsDLEDGsP
0 5 S431‑p SsDLEDGsPRRsQEL
0 1 S435‑p EDGsPRRsQELSLPQ
0 7 S450‑p DLEDTQLsDKGCLAG
0 11 S460‑p GCLAGGGsPKQPFAA
0 1 S483‑p NPHDAGLsSGEPPEK
0 3 S498‑p ERRRLKEsFENYRRK
1 1 T531‑p NTTGSDNtDtEGS__
1 1 T533‑p TGSDNtDtEGS____
  mouse

 
S2‑p ______MsDYENDDE
Y76 QRTGHKGYVAFLESL
S82 GYVAFLESLELYYPQ
Y86 FLESLELYYPQLYRK
Y87 LESLELYYPQLYRKV
Y91 ELYYPQLYRKVtGKE
T95‑p PQLYRKVtGKEPARV
K125 LLMTEVMKLQKKVQD
S152‑p KELRVKDsLLRKHQE
T231 CKVERKHTLKLRHAM
N276 QEGKLDRNSPYIQVL
S277 EGKLDRNSPYIQVLE
Y339 LRKDAKMYKDRIEAI
S354‑p LLQMEEVsIERDQAM
S424‑p QLDMLILssDLEDSs
S425‑p LDMLILssDLEDSsP
S431‑p ssDLEDSsPRNSQEL
S435 EDSsPRNSQELSLPQ
S451‑p LEEDAQLsDKGVLAD
S461‑p GVLADREsPEQPFMA
S483 LTHGMGPSSSEPPEK
S498‑p ERRRLKEsFENYRRK
T531 NTTGSDNTDTEGS__
T533 TGSDNTDTEGS____
  rat

 
S2‑p ______MsDYENDDE
Y76 QRTGHKGYVAFLEsL
S82‑p GYVAFLEsLELYyPQ
Y86 FLEsLELYyPQLyRK
Y87‑p LEsLELYyPQLyRKV
Y91‑p ELYyPQLyRKVTGKE
T95 PQLyRKVTGKEPARV
K125 LLMTEVMKLQKKVQD
S152 KELRVKDSLLRKHQE
T231 CKVERKHTLKLRHAM
N276 QEGKLHRNSPYIQVL
S277 EGKLHRNSPYIQVLE
Y339 LRKDAKMYKDRIEAI
S354 LQQMEEVSIERDQAM
S424‑p QLDMLILssDLEDSS
S425‑p LDMLILssDLEDSSP
S431 ssDLEDSSPRNSQEL
S435 EDSSPRNSQELSLPQ
S451‑p LEEDAQLsDKGVLAD
S461‑p GVLADREsPEQPFVV
S483 QTHDTVPSSSEPPEK
S498 ERRRLKESFENYRRK
T531 NTTGSDNTDTEGS__
T533 TGSDNTDTEGS____
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