a DNA topoisomerase. Controls of topological states of DNA by transient breakage and rejoining of DNA. Makes double-strand breaks. Four splice variant isoforms have been described. Note: This description may include information from UniProtKB.
Cellular Component: centriole; DNA topoisomerase complex (ATP-hydrolyzing); nuclear chromosome; nucleolus; nucleoplasm; nucleus; protein complex
Molecular Function: chromatin binding; DNA bending activity; DNA binding; DNA topoisomerase (ATP-hydrolyzing) activity; DNA-dependent ATPase activity; drug binding; enzyme binding; histone deacetylase binding; magnesium ion binding; protein binding; protein C-terminus binding; protein heterodimerization activity; protein homodimerization activity; protein kinase C binding; ubiquitin binding
Biological Process: apoptotic chromosome condensation; chromosome segregation; DNA ligation; DNA topological change; DNA unwinding during replication; mitotic recombination; positive regulation of apoptosis; positive regulation of retroviral genome replication; positive regulation of viral genome replication; protein sumoylation; regulation of circadian rhythm; resolution of meiotic joint molecules as recombinants; response to DNA damage stimulus; sister chromatid segregation