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Protein Page:
UGT1A3 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
UGT1A3 UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Belongs to the UDP-glycosyltransferase family. 1 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Xenobiotic Metabolism - drug metabolism - cytochrome P450; Cofactor and Vitamin Metabolism - retinol; Transferase; Carbohydrate Metabolism - pentose and glucuronate interconversions; Xenobiotic Metabolism - drug metabolism - other enzymes; Lipid Metabolism - androgen and estrogen; Xenobiotic Metabolism - metabolism by cytochrome P450; Carbohydrate Metabolism - starch and sucrose; Membrane protein, integral; Carbohydrate Metabolism - ascorbate and aldarate; EC 2.4.1.17; Cofactor and Vitamin Metabolism - porphyrin and chlorophyll
Chromosomal Location of Human Ortholog: 2q37
Cellular Component: endoplasmic reticulum
Molecular Function: glucuronosyltransferase activity; protein heterodimerization activity; protein homodimerization activity; retinoic acid binding
Biological Process: flavonoid biosynthetic process; metabolic process; retinoic acid metabolic process
Reference #:  P35503 (UniProtKB)
Alt. Names/Synonyms: GNT1; UD13; UDP glucuronosyltransferase 1 family, polypeptide A3; UDP glucuronosyltransferase 1A3; UDP glycosyltransferase 1 family, polypeptide A3; UDP-glucuronosyltransferase 1-3; UDP-glucuronosyltransferase 1-C; UDP-glucuronosyltransferase 1A3; UDPGT; UDPGT 1-3; UGT-1C; UGT1; UGT1*3; UGT1-03; UGT1.3; UGT1A3; UGT1C
Gene Symbols: UGT1A3
Molecular weight: 60,338 Da
Basal Isoelectric point: 8.41  Predict pI for various phosphorylation states
Select Structure to View Below

UGT1A3

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 1 S43‑p IDGSHWLsMREVLRE
0 1 K108 FETEHFLKKFFRSMA
0 1 Y164‑p CAAVLAKyLsIPTVF
0 1 S166‑p AVLAKyLsIPTVFFL
0 1 Y338‑p PQTVLWRyTGTRPSN
0 11 K354 ANNTILVKWLPQNDL
0 1 K438‑ac VINDKSYkENIMRLS
  mouse

 
S42 MEGSQWLSMRDVVRE
K107‑ac FKTQHFVkAFFETTA
Y163 CGAVLAKYLQIPAVF
Q165 AVLAKYLQIPAVFIL
Y337 PQTVLWRYTGTRPSN
K353‑ac AKNTILVkWLPQNDL
K437 VINNKSYKENIMRLS
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