Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Protein Page:
TLR6 (human)

Overview
TLR6 Participates in the innate immune response to Gram- positive bacteria and fungi. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR2. Belongs to the Toll-like receptor family. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, misc.
Chromosomal Location of Human Ortholog: 4p14
Cellular Component: Golgi apparatus; integral to plasma membrane; lipid raft; phagocytic vesicle membrane; plasma membrane
Molecular Function: protein binding; receptor activity; transmembrane receptor activity
Biological Process: activation of NF-kappaB-inducing kinase; defense response to bacterium; detection of diacylated bacterial lipoprotein; immune response; inflammatory response; innate immune response; interleukin-1 beta secretion; MyD88-dependent toll-like receptor signaling pathway; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of interleukin-6 biosynthetic process; positive regulation of JNK activity; regulation of cytokine secretion; signal transduction; T-helper 1 type immune response; toll-like receptor 6 signaling pathway; toll-like receptor signaling pathway
Reference #:  Q9Y2C9 (UniProtKB)
Gene Symbols: TLR6
Molecular weight: 91,880 Da
Basal Isoelectric point: 6.83  Predict pI for various phosphorylation states
CST Pathways:  NF-kB Signaling  |  Toll-Like Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TLR6

Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script


STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB


Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S116‑p HNQLQKIsCHPIVSF
0 1 S464‑p LHSNKIKsVPKQVVK
0 1 S647‑p LQFHAFIsysEHDsA
0 1 Y648‑p QFHAFIsysEHDsAW
0 1 S649‑p FHAFIsysEHDsAWV
0 1 S653‑p IsysEHDsAWVKSEL
0 1 A780 FWANIRAAFNMKLtL
0 1 T786‑p AAFNMKLtLVtENND
0 1 T789‑p NMKLtLVtENNDVKs
0 1 S796‑p tENNDVKs_______
  mouse

 
S116 HNRLQNISCCPMASL
S464 LHNNRIMSIPKDVTH
S647 LQFHAFVSYSEHDSA
Y648 QFHAFVSYSEHDSAW
S649 FHAFVSYSEHDSAWV
S653 VSYSEHDSAWVKNEL
S780‑p FWANLRAsFIMKLAL
A786 AsFIMKLALVNEDDV
N789 IMKLALVNEDDVKT_
T795 VNEDDVKT_______
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.