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Protein Page:
IGFBP2 (human)
rdtyret
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
IGFBP2 Inhibits IGF-mediated growth and developmental rates. IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Binds IGF2 more than IGF1. Note: This description may include information from UniProtKB.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 2q35
Cellular Component: apical plasma membrane; cytoplasmic vesicle; extracellular region; extracellular space
Molecular Function: insulin-like growth factor I binding; insulin-like growth factor II binding; protein binding
Biological Process: aging; cellular protein metabolic process; cellular response to hormone stimulus; female pregnancy; positive regulation of activated T cell proliferation; regulation of cell growth; regulation of insulin-like growth factor receptor signaling pathway; response to drug; response to estradiol stimulus; response to glucocorticoid stimulus; response to lithium ion; response to mechanical stimulus; response to nutrient; response to retinoic acid; signal transduction
Reference #:  P18065 (UniProtKB)
Alt. Names/Synonyms: BP2; IBP-2; IBP2; IGF-binding protein 2; IGF-BP53; IGFBP-2; IGFBP2; insulin-like growth factor binding protein 2, 36kDa; Insulin-like growth factor-binding protein 2
Gene Symbols: IGFBP2
Molecular weight: 34,814 Da
Basal Isoelectric point: 7.48  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

IGFBP2

Protein Structure Not Found.


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Modification Sites and Domains  
Click here to view other types of protein modifications

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 Y112 CGQGLRCYPHPGSEL
1 1 S142‑p RDAEYGAsPEQVADN
0 1 K186 KPLKSGMKELAVFRE
0 1 T196‑p AVFREKVtEQHRQMG
0 1 K207‑ac RQMGKGGkHHLGLEE
0 1 T299‑p KLIQGAPtIRGDPEC
  mouse

 
Y96 CAQTLRCYPNPGSEL
T123 EKRRVGTTPQQVADS
K167‑ub KPLKSGMkELAVFRE
N177 AVFREKVNEQHRQMG
K188 RQMGKGAKHLSLEEP
T279 KPIQGAPTIRGDPEC
  rat

 
Y96‑p CAQTLRCyPNPGSEL
T123 EKRRVGATPQQVADS
K166 KPPKSGMKELAVFRE
N176 AVFREKVNEQHRQMG
K187 RQMGKGAKHLSLEEP
T278 KPIQGAPTIRGDPEC
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