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Protein Page:
PLXNA4 (human)

Overview
PLXNA4 Coreceptor for SEMA3A. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm. Interacts with NRP1 and NRP2. Belongs to the plexin family. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 7q32.3
Cellular Component: integral to plasma membrane; plasma membrane
Molecular Function: semaphorin receptor activity
Biological Process: branchiomotor neuron axon guidance; regulation of axon extension involved in axon guidance; regulation of cell migration
Reference #:  Q9HCM2 (UniProtKB)
Alt. Names/Synonyms: DKFZp434G0625; DKFZp566O0546; FAYV2820; FLJ35026; FLJ38287; KIAA1550; PLEXA4; plexin A4; Plexin-A4; PLXA4; PLXNA4; PLXNA4A; PLXNA4B; PRO34003
Gene Symbols: PLXNA4
Molecular weight: 212,455 Da
Basal Isoelectric point: 6.42  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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PLXNA4

Protein Structure Not Found.
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