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Protein Page:
PCK2 (human)

Overview
PCK2 Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle. Monomer. Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - citrate (TCA) cycle; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 4.1.1.32; Kinase, other; Lyase; Mitochondrial
Chromosomal Location of Human Ortholog: 14q11.2
Cellular Component: mitochondrial matrix; mitochondrion
Molecular Function: phosphoenolpyruvate carboxykinase (GTP) activity; phosphoenolpyruvate carboxykinase activity
Biological Process: gluconeogenesis
Disease: Phosphoenolpyruvate Carboxykinase Deficiency, Mitochondrial
Reference #:  Q16822 (UniProtKB)
Alt. Names/Synonyms: PCK2; PCKGM; PEP carboxykinase; PEPCK; PEPCK-M; PEPCK2; phosphoenolpyruvate carboxykinase 2 (mitochondrial); Phosphoenolpyruvate carboxykinase [GTP], mitochondrial; Phosphoenolpyruvate carboxylase; phosphopyruvate carboxylase
Gene Symbols: PCK2
Molecular weight: 70,730 Da
Basal Isoelectric point: 7.57  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PCK2

Protein Structure Not Found.


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