Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Protein Page:
EVI1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
EVI1 a zinc finger transcriptional regulator that binds to DNA sequences in the promoter region of target genes and positively or negatively regulates their expression. An oncogene which plays a role in development, cell proliferation and differentiation. May also play a role in apoptosis through regulation of the JNK and TGF-beta signaling. Involved in hematopoiesis. Originally identified as a common site of viral integration in murine myeloid leukemia. Involved in human myeloid disorders through chromosome translocation and inversion and is also implicated in solid tumor formation. At least six isoforms of the human protein are formed due to alternative usage of 5'-ends, alternative splicing, and intergenic splicing which results in the formation of a fusion protein with MDS1, which can be expressed in normal tissues. Note: This description may include information from UniProtKB.
Protein type: Methyltransferase, protein lysine, predicted; Transcription, coactivator/corepressor; Transcription regulation; Oncoprotein; C2H2-type zinc finger protein
Chromosomal Location of Human Ortholog: 3q26.2
Cellular Component: cytoplasm; cytosol; Golgi apparatus; histone deacetylase complex; intracellular membrane-bound organelle; nuclear speck; nucleoplasm; nucleus
Molecular Function: DNA binding; histone-lysine N-methyltransferase activity; metal ion binding; protein binding; protein homodimerization activity; transcription factor activity
Biological Process: apoptosis; cell differentiation; negative regulation of JNK cascade; negative regulation of programmed cell death; negative regulation of transcription, DNA-dependent; negative regulation of transforming growth factor beta receptor signaling pathway; positive regulation of transcription, DNA-dependent; regulation of cell cycle; regulation of transcription, DNA-dependent; transcription, DNA-dependent
Reference #:  Q03112 (UniProtKB)
Alt. Names/Synonyms: AML1-EVI-1 fusion partner; ecotropic viral integration site 1; Ecotropic virus integration site 1 protein homolog; EVI-1; EVI1; MDS1; MDS1 and EVI1 complex locus; MDS1 and EVI1 complex locus protein EVI1; MDS1 and EVI1 complex locus protein MDS1; MDS1-EVI1; MECOM; MGC163392; MGC97004; myelodysplasia syndrome 1 protein; myelodysplasia syndrome-associated protein 1; oncogene EVI1; PRDM3; zinc finger protein Evi1
Gene Symbols: MECOM
Molecular weight: 118,276 Da
Basal Isoelectric point: 6.27  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

EVI1

Protein Structure Not Found.


STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein


Sites Implicated In
transcription, induced: S538‑p, S858‑p
transcription, inhibited: S196‑p
molecular association, regulation: S196‑p, S538‑p, S858‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 S64‑p DFQQKLEsENDLQEI
0 1 S173‑p GKTFATSsGLKQHKH
1 0 S196‑p ICEVCHKsYTQFSNL
0 1 T215‑p RMHADCRtQIKCKDC
0 4 S338‑p EQTNKSQsPLMtHPQ
0 1 T342‑p KSQsPLMtHPQILPA
0 10 S436‑p KMFKDKVsPLQNLAS
0 1 K497‑ub LVGLQDKkVGALPYP
0 1 S529‑p FPDRDLRsLPLKMEP
1 7 S538‑p PLKMEPQsPGEVKKL
0 1 G540 KMEPQsPGEVKKLQK
0 6 S552‑p LQKGSSEsPFDLTTK
1 0 K564‑ac TTKRKDEkPLtPVPS
0 1 T567‑p RKDEkPLtPVPSKPP
0 1 K599 RSRASGTKLTEPRKN
0 1 T649‑p RVEKRKLtDPLEALK
0 1 S818‑p KHENGNMsGTATSSP
0 1 S827‑p TATSSPHsELEsTGA
0 1 S831‑p SPHsELEsTGAILDD
0 7 S854‑p IRNFIGNsNHGsQsP
1 4 S858‑p IGNsNHGsQsPRNVE
1 22 S860‑p NsNHGsQsPRNVEER
1 1 S885‑p ALVTSQNsDLLDDEE
0 1 S986‑p YSEAELSsFstSHVP
0 1 S988‑p EAELSsFstSHVPEE
0 1 T989‑p AELSsFstSHVPEEL
0 1 K1005‑ac QPLHRKSkSQAyAMM
0 1 Y1009‑p RKSkSQAyAMMLSLS
  EVI1 iso3  
S252 DFQQKLESENDLQEI
S361 GKTFATSSGLKQHKH
S384 ICEVCHKSYTQFSNL
T403 RMHADCRTQIKCKDC
S526 EQTNKSQSPLMTHPQ
T530 KSQSPLMTHPQILPA
S624 KMFKDKVSPLQNLAS
K685 LVGLQDKKVGALPYP
S717 FPDRDLRSLPLKMEP
S726 PLKMEPQSPGEVKKL
G728 KMEPQSPGEVKKLQK
S740 LQKGSSESPFDLTTK
K752 TTKRKDEKPLTPVPS
T755 RKDEKPLTPVPSKPP
K787 RSRASGTKLTEPRKN
T837 RVEKRKLTDPLEALK
S1006 KHENGNMSGTATSSP
S1015 TATSSPHSELESTGA
S1019 SPHSELESTGAILDD
S1042 IRNFIGNSNHGSQSP
S1046 IGNSNHGSQSPRNVE
S1048 NSNHGSQSPRNVEER
S1073 ALVTSQNSDLLDDEE
S1174 YSEAELSSFSTSHVP
S1176 EAELSSFSTSHVPEE
T1177 AELSSFSTSHVPEEL
K1193 QPLHRKSKSQAYAMM
Y1197 RKSKSQAYAMMLSLS
  EVI1 iso4  
S128 DFQQKLESENDLQEI
S238 GKTFATSSGLKQHKH
S261 ICEVCHKSYTQFSNL
T280 RMHADCRTQIKCKDC
S403 EQTNKSQSPLMTHPQ
T407 KSQSPLMTHPQILPA
S501 KMFKDKVSPLQNLAS
K562 LVGLQDKKVGALPYP
S594 FPDRDLRSLPLKMEP
S603 PLKMEPQSPGEVKKL
G605 KMEPQSPGEVKKLQK
S617 LQKGSSESPFDLTTK
K629 TTKRKDEKPLTPVPS
T632 RKDEKPLTPVPSKPP
K664 RSRASGTKLTEPRKN
T714 RVEKRKLTDPLEALK
S883 KHENGNMSGTATSSP
S892 TATSSPHSELESTGA
S896 SPHSELESTGAILDD
S919 IRNFIGNSNHGSQSP
S923 IGNSNHGSQSPRNVE
S925 NSNHGSQSPRNVEER
S950 ALVTSQNSDLLDDEE
S1051 YSEAELSSFSTSHVP
S1053 EAELSSFSTSHVPEE
T1054 AELSSFSTSHVPEEL
K1070 QPLHRKSKSQAYAMM
Y1074 RKSKSQAYAMMLSLS
  EVI1 iso6  
S64 DFQQKLESENDLQEI
S174 GKTFATSSGLKQHKH
S197 ICEVCHKSYTQFSNL
T216 RMHADCRTQIKCKDC
S339 EQTNKSQSPLMTHPQ
T343 KSQSPLMTHPQILPA
S437 KMFKDKVSPLQNLAS
K498 LVGLQDKKVGALPYP
S530 FPDRDLRSLPLKMEP
S539 PLKMEPQSPGEVKKL
G541 KMEPQSPGEVKKLQK
S553 LQKGSSESPFDLTTK
K565 TTKRKDEKPLTPVPS
T568 RKDEKPLTPVPSKPP
K600 RSRASGTKLTEPRKN
T650 RVEKRKLTDPLEALK
S810 KHENGNMSGTATSSP
S819 TATSSPHSELESTGA
S823 SPHSELESTGAILDD
S846 IRNFIGNSNHGSQSP
S850 IGNSNHGSQSPRNVE
S852 NSNHGSQSPRNVEER
S877 ALVTSQNSDLLDDEE
S978 YSEAELSSFSTSHVP
S980 EAELSSFSTSHVPEE
T981 AELSSFSTSHVPEEL
K997 QPLHRKSKSQAYAMM
Y1001 RKSKSQAYAMMLSLS
  mouse

 
S64 DLQQNLESESDLREI
S173 GKTFATSSGLKQHKH
S196 ICEVCHKSYTQFSNL
T215 RMHADCRTQIKCKDC
S338‑p EQSNKCQsPLLTHPQ
T342 KCQsPLLTHPQILPA
S436‑p KMFKDKVsPLQNLAS
K497 LVGLQDKKVGALPYP
S529 FPDRDLRSLPLKMEP
S538‑p PLKMEPQsPsEVKKL
S540‑p KMEPQsPsEVKKLQK
S552‑p LQKGSSEsPFDLTTK
K564 TTKRKDEKPLTSGPS
T567 RKDEKPLTSGPSKPS
K599‑ac RGRASGTkLTEPRKN
T649‑p RVEKRKLtDPLEALK
S809 KHENGNMSGTATSSP
S818 TATSSPHSELESAGA
S822 SPHSELESAGAILDD
S845‑p IRNFIGNsNHGsQsP
S849‑p IGNsNHGsQsPRNME
S851‑p NsNHGsQsPRNMEER
S876 ALATSQNSDLLDDEE
S977 YTDAELSSISSSHVP
S979 DAELSSISSSHVPEE
S980 AELSSISSSHVPEEL
K996 QTLHRKSKSQAYAMM
Y1000 RKSKSQAYAMMLSLS
  rat

 
- gap
- gap
S63 SSEVCHKSYTQFSNL
T82 RMHADCRTQIKCKDC
S205 EQSNKCQSPLLTHPQ
T209 KCQSPLLTHPQILPA
S303 KMFKDKVSPLQNLAS
K364 LVGLQDKKVGALPYP
S396 FPDRDLRSLPLKMEP
S405 PLKMEPQSPSEVKKL
S407 KMEPQSPSEVKKLQK
S419 LQKGSSESPFDLTTK
K431 TTKRKDEKPLTSGSS
T434 RKDEKPLTSGSSKLP
K466 RSRASGTKLTEPRKN
T516 RVEKRKLTDPLEALK
S685 KHENGNMSGTATSSP
S694 TATSSPHSELESAGA
S698 SPHSELESAGAILDD
S721 IRNFIGNSNHGSQsP
S725 IGNSNHGSQsPRNME
S727‑p NSNHGSQsPRNMEER
S752‑p ALATSQNsDLLDDEE
- gap
- gap
S855 DAELSFGSSHVPEEL
K871 QPLHRKSKSQAYAMM
Y875 RKSKSQAYAMMLSLS
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.