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Protein Page:
EVI1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
EVI1 a zinc finger transcriptional regulator that binds to DNA sequences in the promoter region of target genes and positively or negatively regulates their expression. An oncogene which plays a role in development, cell proliferation and differentiation. May also play a role in apoptosis through regulation of the JNK and TGF-beta signaling. Involved in hematopoiesis. Originally identified as a common site of viral integration in murine myeloid leukemia. Involved in human myeloid disorders through chromosome translocation and inversion and is also implicated in solid tumor formation. At least six isoforms of the human protein are formed due to alternative usage of 5'-ends, alternative splicing, and intergenic splicing which results in the formation of a fusion protein with MDS1, which can be expressed in normal tissues. Note: This description may include information from UniProtKB.
Protein type: Transcription, coactivator/corepressor; Oncoprotein; C2H2-type zinc finger protein; Transcription regulation; Methyltransferase, protein lysine, predicted
Chromosomal Location of Human Ortholog: 3q26.2
Cellular Component: cytoplasm; cytosol; Golgi apparatus; histone deacetylase complex; intracellular membrane-bound organelle; nuclear speck; nucleoplasm; nucleus
Molecular Function: DNA binding; histone-lysine N-methyltransferase activity; protein binding; transcription factor activity
Biological Process: negative regulation of JNK cascade; negative regulation of programmed cell death; negative regulation of transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; regulation of cell cycle
Reference #:  Q03112 (UniProtKB)
Alt. Names/Synonyms: AML1-EVI-1 fusion partner; ecotropic viral integration site 1; Ecotropic virus integration site 1 protein homolog; EVI-1; EVI1; MDS1; MDS1 and EVI1 complex locus; MDS1 and EVI1 complex locus protein EVI1; MDS1 and EVI1 complex locus protein MDS1; MDS1-EVI1; MECOM; MGC163392; MGC97004; myelodysplasia syndrome 1 protein; myelodysplasia syndrome-associated protein 1; oncogene EVI1; PRDM3; zinc finger protein Evi1
Gene Symbols: MECOM
Molecular weight: 118,276 Da
Basal Isoelectric point: 6.27  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

EVI1

Protein Structure Not Found.


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Sites Implicated In
transcription, induced: S538‑p, S858‑p
transcription, inhibited: S196‑p
molecular association, regulation: S196‑p, S538‑p, S858‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 K2‑sm ______MkSEDYPHE
0 1 S64‑p DFQQKLEsENDLQEI
0 1 S173‑p GKTFATSsGLKQHKH
0 1 K186‑sm KHIHSSVkPFICEVC
1 0 S196‑p ICEVCHKsYTQFSNL
0 1 T215‑p RMHADCRtQIKCKDC
0 4 S338‑p EQTNKSQsPLMtHPQ
0 1 T342‑p KSQsPLMtHPQILPA
0 1 K367‑sm HPSVGDNkPVELQPE
0 1 K434‑sm NGKMFKDkVsPLQNL
0 10 S436‑p KMFKDkVsPLQNLAS
0 1 K447‑sm NLASINNkKEYSNHS
0 1 K497‑ub LVGLQDKkVGALPYP
0 1 K497‑sm LVGLQDKkVGALPYP
0 1 S529‑p FPDRDLRsLPLkMEP
0 1 K533‑sm DLRsLPLkMEPQsPG
1 7 S538‑p PLkMEPQsPGEVKKL
0 1 G540 kMEPQsPGEVKKLQk
0 1 K547‑sm GEVKKLQkGSSEsPF
0 6 S552‑p LQkGSSEsPFDLTTK
1 0 K564‑ac TTKRKDEkPLtPVPS
0 1 K564‑sm TTKRKDEkPLtPVPS
0 1 T567‑p RKDEkPLtPVPSKPP
0 1 K599 RSRASGTKLTEPRKN
0 1 K599‑sm RSRASGTkLTEPRKN
0 1 K647‑sm IYRVEKRkLtDPLEA
0 1 T649‑p RVEKRkLtDPLEALK
0 1 K698‑sm LESFSALkPEASELL
0 1 S818‑p KHENGNMsGTATSSP
0 1 S827‑p TATSSPHsELEsTGA
0 1 S831‑p SPHsELEsTGAILDD
0 7 S854‑p IRNFIGNsNHGsQsP
1 4 S858‑p IGNsNHGsQsPRNVE
1 22 S860‑p NsNHGsQsPRNVEER
0 1 K874‑sm RMNGSHFkDEKALVT
1 1 S885‑p ALVTSQNsDLLDDEE
0 1 K948‑sm KTSPVRYkEEEYkSG
0 1 K953‑sm RYkEEEYkSGLSALD
0 1 K970‑sm RHFTDSLkMRkMEDN
0 1 K973‑sm TDSLkMRkMEDNQYS
0 1 S986‑p YSEAELSsFstSHVP
0 1 S988‑p EAELSsFstSHVPEE
0 1 T989‑p AELSsFstSHVPEEL
0 1 K1005‑ac QPLHRKSkSQAyAMM
0 1 K1005‑sm QPLHRKSkSQAyAMM
0 1 Y1009‑p RKSkSQAyAMMLSLS
  EVI1 iso3  
K190‑sm EELLLFMkSEDYPHE
S252 DFQQKLESENDLQEI
S361 GKTFATSSGLKQHKH
K374 KHIHSSVKPFICEVC
S384 ICEVCHKSYTQFSNL
T403 RMHADCRTQIKCKDC
S526 EQTNKSQSPLMTHPQ
T530 KSQSPLMTHPQILPA
K555 HPSVGDNKPVELQPE
K622 NGKMFKDKVSPLQNL
S624 KMFKDKVSPLQNLAS
K635 NLASINNKKEYSNHS
K685 LVGLQDKKVGALPYP
K685 LVGLQDKKVGALPYP
S717 FPDRDLRSLPLKMEP
K721 DLRSLPLKMEPQSPG
S726 PLKMEPQSPGEVKKL
G728 KMEPQSPGEVKKLQK
K735 GEVKKLQKGSSESPF
S740 LQKGSSESPFDLTTK
K752 TTKRKDEKPLTPVPS
K752 TTKRKDEKPLTPVPS
T755 RKDEKPLTPVPSKPP
K787 RSRASGTKLTEPRKN
K787 RSRASGTKLTEPRKN
K835 IYRVEKRKLTDPLEA
T837 RVEKRKLTDPLEALK
K886 LESFSALKPEASELL
S1006 KHENGNMSGTATSSP
S1015 TATSSPHSELESTGA
S1019 SPHSELESTGAILDD
S1042 IRNFIGNSNHGSQSP
S1046 IGNSNHGSQSPRNVE
S1048 NSNHGSQSPRNVEER
K1062 RMNGSHFKDEKALVT
S1073 ALVTSQNSDLLDDEE
K1136 KTSPVRYKEEEYKSG
K1141 RYKEEEYKSGLSALD
K1158 RHFTDSLKMRKMEDN
K1161 TDSLKMRKMEDNQYS
S1174 YSEAELSSFSTSHVP
S1176 EAELSSFSTSHVPEE
T1177 AELSSFSTSHVPEEL
K1193 QPLHRKSKSQAYAMM
K1193 QPLHRKSKSQAYAMM
Y1197 RKSKSQAYAMMLSLS
  EVI1 iso4  
K66 EELLLFMKSEDYPHE
S128 DFQQKLESENDLQEI
S238 GKTFATSSGLKQHKH
K251 KHIHSSVKPFICEVC
S261 ICEVCHKSYTQFSNL
T280 RMHADCRTQIKCKDC
S403 EQTNKSQSPLMTHPQ
T407 KSQSPLMTHPQILPA
K432 HPSVGDNKPVELQPE
K499 NGKMFKDKVSPLQNL
S501 KMFKDKVSPLQNLAS
K512 NLASINNKKEYSNHS
K562 LVGLQDKKVGALPYP
K562 LVGLQDKKVGALPYP
S594 FPDRDLRSLPLKMEP
K598 DLRSLPLKMEPQSPG
S603 PLKMEPQSPGEVKKL
G605 KMEPQSPGEVKKLQK
K612 GEVKKLQKGSSESPF
S617 LQKGSSESPFDLTTK
K629 TTKRKDEKPLTPVPS
K629 TTKRKDEKPLTPVPS
T632 RKDEKPLTPVPSKPP
K664 RSRASGTKLTEPRKN
K664 RSRASGTKLTEPRKN
K712 IYRVEKRKLTDPLEA
T714 RVEKRKLTDPLEALK
K763 LESFSALKPEASELL
S883 KHENGNMSGTATSSP
S892 TATSSPHSELESTGA
S896 SPHSELESTGAILDD
S919 IRNFIGNSNHGSQSP
S923 IGNSNHGSQSPRNVE
S925 NSNHGSQSPRNVEER
K939 RMNGSHFKDEKALVT
S950 ALVTSQNSDLLDDEE
K1013 KTSPVRYKEEEYKSG
K1018 RYKEEEYKSGLSALD
K1035 RHFTDSLKMRKMEDN
K1038 TDSLKMRKMEDNQYS
S1051 YSEAELSSFSTSHVP
S1053 EAELSSFSTSHVPEE
T1054 AELSSFSTSHVPEEL
K1070 QPLHRKSKSQAYAMM
K1070 QPLHRKSKSQAYAMM
Y1074 RKSKSQAYAMMLSLS
  EVI1 iso6  
K2 ______MKSEDYPHE
S64 DFQQKLESENDLQEI
S174 GKTFATSSGLKQHKH
K187 KHIHSSVKPFICEVC
S197 ICEVCHKSYTQFSNL
T216 RMHADCRTQIKCKDC
S339 EQTNKSQSPLMTHPQ
T343 KSQSPLMTHPQILPA
K368 HPSVGDNKPVELQPE
K435 NGKMFKDKVSPLQNL
S437 KMFKDKVSPLQNLAS
K448 NLASINNKKEYSNHS
K498 LVGLQDKKVGALPYP
K498 LVGLQDKKVGALPYP
S530 FPDRDLRSLPLKMEP
K534 DLRSLPLKMEPQSPG
S539 PLKMEPQSPGEVKKL
G541 KMEPQSPGEVKKLQK
K548 GEVKKLQKGSSESPF
S553 LQKGSSESPFDLTTK
K565 TTKRKDEKPLTPVPS
K565 TTKRKDEKPLTPVPS
T568 RKDEKPLTPVPSKPP
K600 RSRASGTKLTEPRKN
K600 RSRASGTKLTEPRKN
K648 IYRVEKRKLTDPLEA
T650 RVEKRKLTDPLEALK
K690 LESFSALKPEASELL
S810 KHENGNMSGTATSSP
S819 TATSSPHSELESTGA
S823 SPHSELESTGAILDD
S846 IRNFIGNSNHGSQSP
S850 IGNSNHGSQSPRNVE
S852 NSNHGSQSPRNVEER
K866 RMNGSHFKDEKALVT
S877 ALVTSQNSDLLDDEE
K940 KTSPVRYKEEEYKSG
K945 RYKEEEYKSGLSALD
K962 RHFTDSLKMRKMEDN
K965 TDSLKMRKMEDNQYS
S978 YSEAELSSFSTSHVP
S980 EAELSSFSTSHVPEE
T981 AELSSFSTSHVPEEL
K997 QPLHRKSKSQAYAMM
K997 QPLHRKSKSQAYAMM
Y1001 RKSKSQAYAMMLSLS
  mouse

 
K2 ______MKSEEDPHE
S64 DLQQNLESESDLREI
S173 GKTFATSSGLKQHKH
K186 KHIHSSVKPFICEVC
S196 ICEVCHKSYTQFSNL
T215 RMHADCRTQIKCKDC
S338‑p EQSNKCQsPLLTHPQ
T342 KCQsPLLTHPQILPA
K367 HPPVGDNKPVELLPE
K434 NGKMFKDKVsPLQNL
S436‑p KMFKDKVsPLQNLAS
K447 NLASITNKKEHNNHS
K497 LVGLQDKKVGALPYP
K497 LVGLQDKKVGALPYP
S529 FPDRDLRSLPLKMEP
K533 DLRSLPLKMEPQsPs
S538‑p PLKMEPQsPsEVKKL
S540‑p KMEPQsPsEVKKLQK
K547 sEVKKLQKGSSEsPF
S552‑p LQKGSSEsPFDLTTK
K564 TTKRKDEKPLTSGPS
K564 TTKRKDEKPLTSGPS
T567 RKDEKPLTSGPSKPS
K599‑ac RGRASGTkLTEPRKN
K599 RGRASGTKLTEPRKN
K647 IYRVEKRKLtDPLEA
T649‑p RVEKRKLtDPLEALK
K689 LESFSALKPEASELL
S809 KHENGNMSGTATSSP
S818 TATSSPHSELESAGA
S822 SPHSELESAGAILDD
S845‑p IRNFIGNsNHGsQsP
S849‑p IGNsNHGsQsPRNME
S851‑p NsNHGsQsPRNMEER
K865 RMNGSHFKDKKALAT
S876 ALATSQNSDLLDDEE
K939 KASPVRYKEEDYKSG
K944 RYKEEDYKSGLSALD
K961 RHFTDSLKMREMEEN
E964 TDSLKMREMEENQYT
S977 YTDAELSSISSSHVP
S979 DAELSSISSSHVPEE
S980 AELSSISSSHVPEEL
K996 QTLHRKSKSQAYAMM
K996 QTLHRKSKSQAYAMM
Y1000 RKSKSQAYAMMLSLS
  rat

 
- gap
- gap
- gap
- gap
S63 SSEVCHKSYTQFSNL
T82 RMHADCRTQIKCKDC
S205 EQSNKCQSPLLTHPQ
T209 KCQSPLLTHPQILPA
K234 HPPVGDNKPVELLPE
K301 NGKMFKDKVSPLQNL
S303 KMFKDKVSPLQNLAS
K314 NLASINNKKEYSNHS
K364 LVGLQDKKVGALPYP
K364 LVGLQDKKVGALPYP
S396 FPDRDLRSLPLKMEP
K400 DLRSLPLKMEPQSPS
S405 PLKMEPQSPSEVKKL
S407 KMEPQSPSEVKKLQK
K414 SEVKKLQKGSSESPF
S419 LQKGSSESPFDLTTK
K431 TTKRKDEKPLTSGSS
K431 TTKRKDEKPLTSGSS
T434 RKDEKPLTSGSSKLP
K466 RSRASGTKLTEPRKN
K466 RSRASGTKLTEPRKN
K514 IYRVEKRKLTDPLEA
T516 RVEKRKLTDPLEALK
K565 LESFSGLKPEASELL
S685 KHENGNMSGTATSSP
S694 TATSSPHSELESAGA
S698 SPHSELESAGAILDD
S721 IRNFIGNSNHGSQsP
S725 IGNSNHGSQsPRNME
S727‑p NSNHGSQsPRNMEER
K741 RMNGSHFKDEKALAT
S752‑p ALATSQNsDLLDDEE
K815 KVSPVRYKEEDYKSG
K820 RYKEEDYKSGLSALD
K837 RHFTDSLKMREMEEN
E840 TDSLKMREMEENQYT
- gap
- gap
S855 DAELSFGSSHVPEEL
K871 QPLHRKSKSQAYAMM
K871 QPLHRKSKSQAYAMM
Y875 RKSKSQAYAMMLSLS
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