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Protein Page:
DR6 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
DR6 May activate NF-kappa-B and promote apoptosis. May activate JNK and be involved in T-cell differentiation. Required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N- terminal fragment of APP (N-APP). N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6). Associates with TRADD. Interacts with N-APP. Highly expressed in heart, brain, placenta, pancreas, lymph node, thymus and prostate. Detected at lower levels in lung, skeletal muscle, kidney, testis, uterus, small intestine, colon, spleen, bone marrow and fetal liver. Very low levels were found in adult liver and peripheral blood leukocytes. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, cytokine; Apoptosis
Chromosomal Location of Human Ortholog: 6p21.1
Cellular Component: axon; integral to plasma membrane; intrinsic to plasma membrane; plasma membrane
Molecular Function: protein binding; tumor necrosis factor receptor activity
Biological Process: adaptive immune response; apoptosis; B cell apoptosis; humoral immune response; immune response; inflammatory response; myelination; negative regulation of B cell proliferation; negative regulation of myelination; negative regulation of T cell proliferation; neuron apoptosis; regulation of apoptosis; regulation of cell proliferation; regulation of oligodendrocyte differentiation; response to lipopolysaccharide; T cell receptor signaling pathway; tumor necrosis factor-mediated signaling pathway
Reference #:  O75509 (UniProtKB)
Alt. Names/Synonyms: BM-018; Death receptor 6; DR6; MGC31965; TNFR-related death receptor 6; TNFRSF21; TNR21; Tumor necrosis factor receptor superfamily member 21; tumor necrosis factor receptor superfamily, member 21
Gene Symbols: TNFRSF21
Molecular weight: 71,845 Da
Basal Isoelectric point: 8.09  Predict pI for various phosphorylation states
CST Pathways:  Alzheimer's Disease
Select Structure to View Below

DR6

Protein Structure Not Found.
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Download ChimeraX Script


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S4‑p ____MGTsPSSSTAL
0 1 S7 _MGTsPSSSTALAsC
0 1 S13‑p SSSTALAsCSRIARR
0 1 S15 STALAsCSRIARRAt
0 1 T22‑p SRIARRAtAtMIAGS
0 1 T24‑p IARRAtAtMIAGSLL
0 1 S177‑p QCARGTFsDVPssVM
0 1 S181‑p GTFsDVPssVMKCKA
0 1 S182‑p TFsDVPssVMKCKAY
0 1 S315‑p HILKLLPsMEAtGGE
0 1 T319‑p LLPsMEAtGGEKSST
0 1 T376‑p SIRKSSRtLKKGPRQ
0 4 S386‑p KGPRQDPsAIVEKAG
0 2 Y409‑p QNREKWIyyCNGHGI
0 1 Y410‑p NREKWIyyCNGHGID
0 4 Y434‑p GSQWKDIyQFLCNAS
0 32 Y460‑p TADHERAyAALQHWT
0 1 S525‑p LSPSPIPsPNAKLEN
0 1 S533‑p PNAKLENsALLTVEP
0 10 S541‑p ALLTVEPsPQDkNkG
0 1 K545‑ac VEPsPQDkNkGFFVD
0 1 K547‑ac PsPQDkNkGFFVDES
0 27 S562‑p EPLLRCDstssGssA
0 8 T563‑p PLLRCDstssGssAL
0 7 S564‑p LLRCDstssGssALs
0 9 S565‑p LRCDstssGssALsR
0 4 S567‑p CDstssGssALsRNG
0 7 S568‑p DstssGssALsRNGS
0 1 S571‑p ssGssALsRNGSFIT
0 7 Y648‑p QTLLDSVysHLPDLL
0 1 S649‑p TLLDSVysHLPDLL_
7616 : Phospho-DR6 (Ser562) Antibody
  mouse

 
R4 ____MGTRASsITAL
S7‑p _MGTRASsITALASC
S13 SsITALASCsRTAGQ
S15‑p ITALASCsRTAGQVG
G22 sRTAGQVGATMVAGS
T24 TAGQVGATMVAGSLL
S177 QCARGTFSDVPSSVM
S181 GTFSDVPSSVMKCKA
S182 TFSDVPSSVMKCKAH
S315 HILKLLPSSMEATGE
A319 LLPSSMEATGEKSST
T376 SIRKSSRTLKKGPRQ
S386‑p KGPRQDPsAIVEKAG
Y409 QNREKWIYYRNGHGI
Y410 NREKWIYYRNGHGID
Y434 GSQWKDIYQFLCNAS
Y460 TADHERAYAALQHWT
S525 LSPSPMPSPNVKLEN
S533 PNVKLENSTLLTVEP
S541‑p TLLTVEPsPLDKNKC
K545 VEPsPLDKNKCFFVD
K547 PsPLDKNKCFFVDES
S562‑p EPLLRCDsTSSGSSA
T563 PLLRCDsTSSGSSAL
S564 LLRCDsTSSGSSALS
S565 LRCDsTSSGSSALSR
S567 CDsTSSGSSALSRNG
S568 DsTSSGSSALSRNGS
S571 SSGSSALSRNGSFIT
Y648 QTLLDSVYSHLPDLL
S649 TLLDSVYSHLPDLL_
7616 : Phospho-DR6 (Ser562) Antibody
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