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Protein Page:
BCL2L2 (human)

BCL2L2 Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX. Expressed in a wide range of tissues with highest levels in brain, spinal cord, testis, pancreas, heart, spleen and mammary glands. Moderate levels found in thymus, ovary and small intestine. Not detected in salivary gland, muscle or liver. Also expressed in cell lines of myeloid, fibroblast and epithelial origin. Not detected in most lymphoid cell lines. Belongs to the Bcl-2 family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Chromosomal Location of Human Ortholog: 14q11.2-q12
Cellular Component: mitochondrial outer membrane
Molecular Function: protein binding; protein heterodimerization activity; protein homodimerization activity
Biological Process: DNA damage response, signal transduction resulting in induction of apoptosis; negative regulation of apoptosis; spermatogenesis
Reference #:  Q92843 (UniProtKB)
Alt. Names/Synonyms: Apoptosis regulator Bcl-W; B2CL2; Bcl-2-like protein 2; BCL-W; Bcl2-L-2; BCL2-like 2; BCL2-like 2 protein; BCL2L2; BCLW; KIAA0271
Gene Symbols: BCL2L2
Molecular weight: 20,746 Da
Basal Isoelectric point: 5.21  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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