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Protein Page:
EPO (human)

Overview
EPO Erythropoietin is the principal hormone involved in the regulation of erythrocyte differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Genetic variation in EPO is associated with susceptbility to microvascular complications of diabetes type 2 (MVCD2). These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. Belongs to the EPO/TPO family. Note: This description may include information from UniProtKB.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 7q22
Cellular Component: cell surface; extracellular region; extracellular space
Molecular Function: erythropoietin receptor binding; hormone activity; protein binding; protein kinase activator activity
Biological Process: activation of protein kinase activity; acute-phase response; aging; apoptosis; blood circulation; embryo implantation; erythrocyte differentiation; erythrocyte maturation; hemoglobin biosynthetic process; negative regulation of transcription from RNA polymerase II promoter; peptidyl-serine phosphorylation; positive regulation of activated T cell proliferation; positive regulation of cell proliferation; positive regulation of DNA replication; positive regulation of Ras protein signal transduction; positive regulation of transcription, DNA-dependent; positive regulation of tyrosine phosphorylation of Stat5 protein; response to axon injury; response to electrical stimulus; response to estrogen stimulus; response to hyperoxia; response to lipopolysaccharide; response to salt stress; response to testosterone stimulus; response to vitamin A; signal transduction
Disease: Microvascular Complications Of Diabetes, Susceptibility To, 2
Reference #:  P01588 (UniProtKB)
Gene Symbols: EPO
Molecular weight: 21,307 Da
Basal Isoelectric point: 8.3  Predict pI for various phosphorylation states
Select Structure to View Below

EPO

Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 3 S127‑p LHVDKAVsGLRsLTT
0 1 S131‑p KAVsGLRsLTTLLRA
0 1 T161‑p AAPLRTItADTFRKL
  mouse

 
S126 LHIDKAISGLRSLTS
S130 KAISGLRSLTSLLRV
T160 PAPLRTLTVDTFCKL
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