Ubiquitin-like protein required for autophagy. Conjugated to ATG3 and ATG5. Ubiquitous. Belongs to the ATG12 family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Autophagy; Ubiquitin-like modifier
Cellular Component: cytoplasm; membrane; pre-autophagosomal structure membrane; protein complex
Molecular Function: APG8 conjugating enzyme activity; protein binding
Biological Process: autophagic vacuole formation; autophagy; C-terminal protein lipidation; immune system process; innate immune response; mitochondrion degradation
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.